0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
This Month in Archives of Dermatology |

This Month in Archives of Dermatology FREE

[+] Author Affiliations

Section Editor: Robin L. Travers, MD


Arch Dermatol. 2008;144(8):978. doi:10.1001/archderm.144.8.978.
Text Size: A A A
Published online

PERIFOLLICULAR XANTHOMATOSIS AS THE HALLMARK OF AXILLARY FOX-FORDYCE DISEASE

Fox-Fordyce disease (FFD) is a rare condition characterized by apocrine miliaria. Although the sweat retention vesicle has been called the singular diagnostic feature, it is often not easily demonstrated. In this case series, Bormate et al examined biopsy specimens from 7 cases of FFD and confirmed that traditional histopathologic criteria are nonspecific and of little diagnostic help. The recently described peri-infundibular and periductal xanthomatized cells represent a more sensitive and specific means to recognize FFD and may be considered the hallmark in diagnosis.

See page 1020

A COMMUNITY-BASED STUDY OF ACNE-RELATED HEALTH PREFERENCES IN ADOLESCENTS

The psychological impact of acne vulgaris on adolescents has been documented for more than 50 years. Reduction in anxiety, depression, embarrassment, lack of self-confidence, social dysfunction, and even unemployment are potential goals for acne therapy. In this survey of a convenience sample of adolescents, Chen et al demonstrated that adolescents consider 50% clearing or total clearance with scarring to be not much of an improvement over their current level of acne. These data may help dermatologists balance clinical data with their patient's high expectations of therapy, given that randomized, blinded, placebo-controlled trials have shown that 3 to 4 months of conventional acne therapy typically produce lesion count reduction only in the 40% to 60% range.

See page 988

CD8+ EPIDERMOTROPIC CYTOTOXIC T-CELL LYMPHOMA WITH PERIPHERAL BLOOD AND CENTRAL NERVOUS SYSTEM INVOLVEMENT

Cutaneous T-cell lymphomas (CTCLs) are a group of primary malignant neoplasms of skin-homing T cells, usually deriving from CD4+ cells. In rare cases, CD8+ immunophenotypes have been described. In this case report, Introcaso et al describe a patient with a CD8+ epidermotropic T-cell lymphoma that demonstrated the loss of the same T-cell markers CD7 and CD26 that have been previously described as absent in CD4+ CTCLs. The demonstration of the loss of these markers represents a powerful tool for early diagnosis and monitoring of peripheral blood involvement in these patients and allows initiation of appropriate therapy, such as photopheresis or stem cell transplantation, at an earlier point.

See page 1027

HIGH ASSOCIATION OF HUMAN HERPESVIRUS 8 IN LARGE-PLAQUE PARAPSORIASIS AND MYCOSIS FUNGOIDES

Human herpesvirus 8 (HHV-8) has been unambiguously identified as the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Although investigations have failed to demonstrate an association of HHV-8 to the pathogenesis of CTCL, an association with other lymphoproliferative disorders has been suggested. In this retrospective study of 53 patients with lymphoproliferative diseases, Kreuter et al confirmed the previously described association of HHV-8 with large-plaque parapsoriasis (LPP) but also demonstrated low levels of HHV-8 in most of the MF samples. Although no conclusions may be drawn on the etiologic and pathogenic role of HHV-8 in these diseases, HHV-8 may act as a cofactor in the progression of LPP and CTCL.

See page 1011

RETROSPECTIVE EVALUATION OF PATCH TESTING BEFORE OR AFTER METAL DEVICE IMPLANTATION

Implanted devices such as orthopedic prostheses and pacemakers are being increasingly used, raising concerns regarding allergenicity of the devices, particularly the implanted metals. The components of implanted devices may play a role in both device failure and dermatitis. Patch testing represents a means of detecting an allergy to the components of an implanted device. In this retrospective medical chart review, Reed et al demonstrated that preimplantation patch testing, generally performed because of a patient-reported history of metal allergy, was useful in guiding the device selection. Postimplantation patch testing was commonly performed because of unexplained skin eruptions at the implantation site, chronic joint pain, and joint loosening. No patients in this series demonstrated positive reactions to components of their implanted devices, and postimplantation patch testing may be of less value.

See page 999

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

223 Views
0 Citations
×

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs