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Correspondence |

Palmar-Plantar Erythrodysesthesia Caused by Mercaptopurine and Mesalamine

Karolyn A. Wanat, BS; Grace D. Bandow, MD; Paul A. Klekotka, MD, PhD
Arch Dermatol. 2008;144(8):1079-1081. doi:10.1001/archderm.144.8.1079.
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Weinshilboum  RMSladek  SL Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32 (5) 651- 662
Cox  GJRobertson  DB Toxic erythema of palms and soles associated with high-dose mercaptopurine chemotherapy. Arch Dermatol 1986;122 (12) 1413- 1414
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.1986.01660240077020]]
Lowry  PWFranklin  CLWeaver  AL  et al.  Leucopenia resulting from a drug interaction between azathioprine and 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide. Gut 2001;49 (5) 656- 664
PubMed Link to Article[[XSLOpenURL/10.1136/gut.49.5.656]]
Mrozek-Orlowski  MEFrye  DKSanborn  HM Capecitabine: nursing implications of a new oral chemotherapeutic agent. Oncol Nurs Forum 1999;26 (4) 753- 762
Lassere  YHoff  P Management of hand-foot syndrome in patients treated with capecitabine. Eur J Oncol Nurs 2004;8 ((suppl 1)) S31- S40
PubMed Link to Article[[XSLOpenURL/10.1016/j.ejon.2004.06.007]]
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Painful erosions. A, The patient had mild facial edema with superficial erosions of the lips. B, She also had prominent pink papillae on her tongue. C, Her fingers were edematous and tender with well-demarcated, erythematous erosions and adjacent desquamation on all 10 volar fingertips. D, The plantar surfaces of her feet showed prominent desquamation and underlying erosions.

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