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Correspondence |

The Role of Narrowband UV-B Plus Alefacept Combination Therapy in the Treatment of Psoriasis

Heidi Jacobe, MD; Laura Winterfield, MD; Flora Kim, BS; Beverley Huet-Adams, MS; Rachael Cayce, BS
Arch Dermatol. 2008;144(8):1067-1068. doi:10.1001/archderm.144.8.1067.
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In the August 2007 issue of the Archives, Legat et al1 described the accelerated and improved clearance of psoriasis when alefacept is combined with narrowband (NB) UV-B phototherapy. Because all patients in this study were treated with alefacept and with a randomly selected body half exposed to NB UV-B phototherapy, the question remained as to whether the improvement seen was greater than what can be achieved with NB UV-B monotherapy. We present data from 16 patients with chronic plaque psoriasis requiring systemic or phototherapy who were enrolled in an institutional review board approved, randomized, double-blind, placebo-controlled study comparing alefacept with NB UV-B vs NB UV-B alone for the treatment of psoriasis.

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Figure 1.

Reduction from baseline Psoriasis Area Severity Index (PASI) score during the 12-week treatment period and the 8-week posttreatment observation period. No statistical difference in PASI scores was found at 12 weeks using the 2-factor, repeated-measures analysis of variance model (P > .05). NB indicates narrowband.

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Figure 2.

Proportions of patients achieving Psoriasis Area Severity Index (PASI) scores of 50% or 75% by the end of the 12-week treatment period. NB indicates narrowband

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