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Torsemide-Induced Pseudoporphyria

Alicia Pérez-Bustillo, MD; Pedro Sánchez-Sambucety, MD; Óscar Suárez-Amor, MD; Manuel Angel Rodríiguez-Prieto, MD
Arch Dermatol. 2008;144(6):812-813. doi:10.1001/archderm.144.6.812.
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Pseudoporphyria is an infrequent blistering skin disease. The occurrence of this entity has been attributed to exposure to UV radiation, chronic kidney failure associated or not with dialysis, and use of multiple drugs including diuretics.1 To our knowledge, torsemide has not been reported as a cause of pseudoporphyria; likewise, cross-reaction with furosemide had been suspected theoretically but not observed in any patient.

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Figure 1.

Bullae, crusts, erosions, and hypopigmented scars on the backs of the hands.

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Figure 2.

Photomicrograph of lesional skin biopsy specimen demonstrating blood vessels in the papillary dermis with reduplication of the basal membrane (periodic acid-Schiff–diastase stain, original magnification ×20).

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Torsemide-induced pseudoporphyria. Arch Dermatol 2008;144(6):812-3.