Phototherapy has been used as the second-line therapy for atopic dermatitis resistant to topical corticosteroids. The problem with UV therapy is its carcinogenicity in long-term treatment, and the risk may be even higher if multiple courses precede the use of TCIs and cyclosporine. Whole-body cryotherapy, another physical therapy, offers a new option in the armament of therapies for atopic dermatitis. In our patients, whole-body cryotherapy was successfully carried out as monotherapy during the treatment period, ie, no anti-inflammatory topical preparations were used. Thus, it clearly has a steroid-sparing effect with additional statistically and clinically significant improvements in pruritus and sleep disturbances. The findings are in agreement with statistically significant changes in SCORAD and TEWL. The tendencies of SCORAD (data not shown), pruritus, and sleep loss to continue improving even after the treatment period suggests that the ultimate treatment effect was not attained during the 4-week treatment period. Future studies with a higher number of treatment sessions comparable to phototherapy are thus indicated.