Author Contributions: Dr Hsu had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and disign: Van and Hsu. Acquisition of data:Van and Modi. Analysis and interpretation of data: Ban, Modi, Yang, and Hsu. Drafting of the manuscript: Van, Modi, and Yang. Critical revision of the manuscript for important intellectual content: Van, Modi, Yang, and Hsu. Statistical analysis:Van. Study supervision: Yang and Hsu.