It was then decided to cover the areas of epidermal detachment with 4 fresh amniotic membranes (Figure 2), previously tested for human immunodeficiency virus, rapid plasma reagin, cytomegalovirus, Chagas disease, human T-lymphotropic virus 1 (HTLV-1), hepatitis B, and hepatitis C. The same tests were performed in our patient, and findings were positive for HTLV-1 but not the other markers. The amniotic membranes were obtained at the time of a birth by cesarean delivery, rinsed with isotonic sodium chloride solution, and conserved for 12 hours before use in a saline medium with added penicillin. The amniotic membranes were placed under sterile conditions. The patient was kept in a prone position for 24 hours, until the amniotic membranes dried and consequently fixed to the skin. Subsequently she was turned over to a supine position and amniotic membranes were applied on the other side. She was intubated during the whole procedure, and IVIG was maintained concurrently with the application of the amniotic membranes. The findings from the physical examination and laboratory workup showed that she improved dramatically during the following 24 hours with a marked decrease in exudation from denudated areas and control of her pain. A complete reepithelization of the affected skin was observed 5 days after the membrane placement (Figure 3). We obtained a skin biopsy sample from an area with skin detachment on hospital day 1, before IVIG was started, which confirmed the diagnosis of TEN (Figure 4). We also obtained biopsy specimens from an amniotic membrane–covered area with underlying nondetached epidermis on hospital day 10 (5 days after the amnion placement), which showed a nonnecrotic epidermis covered by amniotic membrane remnants and serous exudate. The dermis had a scarce inflammatory infiltrate (Figure 5).