Sunburn is the clinical manifestation of a complex inflammatory process in the skin that is most commonly encountered in fair-skinned individuals following UV radiation exposure. Clinically, erythema develops gradually in the 3 to 5 hours following sun exposure and may persist for more than 48 hours. Symptoms range from mild redness to painful erythema, edema, and blistering. Current therapeutic recommendations often include topical corticosteroids. In this randomized, double-blind, controlled clinical trial, Faurschou and Wulf demonstrate that treatment with moderate- or high-potency topical corticosteroids 6 or 23 hours after sunburn does not decrease the acute sunburn reaction. The authors suggest that this lack of clinical effect may be related to cellular functions being so severely disturbed by UV radiation that the corticosteroids are unable to bind to their intracytoplasmic receptors.