Correspondence |

Interstitial Granulomatous Reaction to Strontium Ranelate

Cheryl Groves, MB, MRCPE; Mairin E. McMenamin, MB, MRCPI, FRCPath; Maureen Casey, MB, MRCPI; Louise Barnes, MD, FRCPI
Arch Dermatol. 2008;144(2):268-269. doi:10.1001/archdermatol.2007.54.
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We report herein the novel occurrence of an interstitial granulomatous drug reaction in response to treatment with strontium ranelate, an anabolic skeletal agent used to treat postmenopausal osteoporosis.

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Fujita  YShimizu  TShimizu  H A case of interstitial granulomatous drug reaction due to sennoside. Br J Dermatol 2004;150 (5) 1035- 1037
Lee  HWYun  WJLee  MW  et al.  Interstitial granulomatous drug reaction caused by Chinese herbal medication. J Am Acad Dermatol 2005;52 (4) 712- 713
Chu  PConnolly  MKLeBoit  PE The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol 1994;130 (10) 1278- 1283
Dyson  SWHirsch  AJaworsky  C Interstitial granulomatous dermatitis secondary to soy. J Am Acad Dermatol 2004;51 (2) ((suppl)) S105- S107
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Figure 1.

Subtle erythematous plaques extending from axilla to upper arm.

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Figure 2.

Histiocytes surrounding eosinophilic collagen bundles (hematoxylin-eosin, original magnification ×20).

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