Acanthosis nigricans presents as asymptomatic tan to dark brown velvety plaques usually on the posterior neck and intertriginous areas. It is often a cutaneous manifestation of insulin resistance. Histopathologically, lesions demonstrate hyperkeratosis, papillomatosis, acanthosis, and a thickened dermis. Acanthosis nigricans at the site of repeated insulin injections has been reported at least twice previously in the literature.1- 2 The activation of insulinlike growth factor (IGF) receptors due to high circulating levels of insulin likely causes this lesion.3
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Presentation of exogenous insulin-derived acanthosis nigricans. A, Circumscribed dark brown plaque on the left lower abdomen. B, Hyperkeratotic, dark brown, verrucous plaque.
Hyperkeratosis, papillomatosis, acanthosis, a thickened dermis, and superficial and deep perivascular infiltrate (hematoxylin-eosin, original magnification ×40).
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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