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Correspondence |

Successful Treatment of Necrobiosis Lipoidica With Antimalarial Agents

François Durupt, MD; Stéphane Dalle, MD; Sébastien Debarbieux, MD; Brigitte Balme, MD; Sandra Ronger, MD; Luc Thomas, MD, PhD
Arch Dermatol. 2008;144(1):118-119. doi:10.1001/archderm.144.1.118.
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Necrobiosis lipoidica (NL) is a rare granulomatous inflammatory skin disease of unknown origin, sometimes associated with diabetes mellitus (DM). The disease is often chronic, and skin lesions can progress toward ulceration and scarring. Many treatments have been proposed, but none show convincing efficacy. We describe herein the first series of patients treated with antimalarial agents for NL. Treatment brought significant improvement for 7 of 8 patients.

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Plaque of necrobiosis lipoidica before (A) and after (B) a 6-month regimen of chloroquine treatment.

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