Between 2000 and 2005, 228 pregnant patients with skin disorders were seen at the Department of Dermatology, Medical University of Graz, Graz, Austria, and entered into the database of our specialized dermatologic pregnancy clinic. Among those 228 patients, 13 cases of ICP could be identified and were retrospectively studied by medical chart review. Approval from the Medical University of Graz ethics committee was obtained for this study. The diagnosis of ICP was based on the following criteria: (1) generalized pruritus with or without skin changes starting in the second half of pregnancy; (2) elevated total serum bile acid levels (>11 μmol/L)2 (to convert to micrograms per milliliter, divide by 2.448); and (3) exclusion of other dermatologic and/or internal conditions known to cause pruritus. The clinical parameters evaluated included age, ethnicity, and medical history (particularly, personal and/or family history of pregnancy-associated pruritus, time of disease onset, presenting signs and symptoms, disease duration, treatment, and maternal outcome). Laboratory results reviewed in all patients included levels of total serum bile acids, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase, total serum alkaline phosphatase, and total serum bilirubin. Scrutinized obstetric parameters were gestation, parity, time and mode of delivery, presence of fetal distress (pathological cardiotocogram and meconium-stained amniotic fluid), neonatal sex, and weight. Data for at least 1 follow-up visit after delivery were available in all patients.