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Correspondence |

Early Melanomas Dermoscopically Characterized by Reticular Depigmentation

Gian Piero Lozzi, MD; Domenico Piccolo, MD; Tamara Micantonio, MD; Davide Altamura, MD; Ketty Peris, MD
Arch Dermatol. 2007;143(6):799-816. doi:10.1001/archderm.143.6.808.
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Reticular depigmentation is a dermoscopic feature defined as an inverse pigment network composed of a whitish net against a dark-pigmented background, and it is commonly observed in Spitz or Reed nevi, dermatofibroma, Clark nevi, and rarely in melanoma.14 However, the presence of other dermoscopic features usually establishes the final diagnosis.24 We report herein 4 cases of early melanoma dermoscopically characterized by reticular depigmentation.

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Figure 1.

Dermoscopic analysis. A, Case 1 shows a peripheral reticular depigmentation and pigment network and irregularly distributed globules. B, In case 2, the reticular depigmentation is associated with brown dots or globules regularly distributed within the lesion. C, In case 3, reticular depigmentation and 2 peripheral brown to gray-blue areas can be observed. D, Case 4 shows central reticular depigmentation, a peripheral typical pigment network, and a peripheral homogeneous dark-brown area. Insets in all panels represent clinical images of the lesions.

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Figure 2.

Histopathologic examination of 2 of the cases represented in Figure 1 (hematoxylin-eosin, original magnification ×100). A, In case 1, melanoma in situ shows atypical melanocytes throughout the whole epidermis. B, Case 3 shows early invasive melanoma characterized by atypical melanocytes in the epidermis and upper dermis (Breslow thickness, 0.2 mm).

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