We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Fast-Growing and Slow-Growing Melanomas

Giuseppe Argenziano, MD; Iris Zalaudek, MD; Gerardo Ferrara, MD
Arch Dermatol. 2007;143(6):799-816. doi:10.1001/archderm.143.6.802.
Text Size: A A A
Published online


We read with great interest the article by Liu et al1 and the accompanying editorial by Lipsker2 on rapidly growing melanomas. Both articles point out that different types of melanomas exist in relation to their biological propensity to grow and metastasize. Based on patient recall, Liu et al1 calculated the rate of growth of 404 invasive melanomas (median tumor thickness, 1.3 mm) and found that almost a third of them grew 0.5 mm per month or more. These rapidly growing melanomas are more likely thick tumors associated with a high mitotic rate and more frequently found in older men with fewer melanocytic nevi and freckles. Furthermore, they usually lack the clinical ABCD features of melanoma (A, asymmetry; B, border irregularity; C, color variegation; D, diameter >5 mm), being frequently symmetric and amelanotic nodules. The authors conclude that the lack of the most important risk factors for melanoma (ie, large number of nevi and freckles) and the lack of the typical melanoma features (ie, ABCD criteria) make it more difficult for the physician to identify this subtype of rapidly growing melanoma.

Figures in this Article



Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption

Clinical (A) and dermoscopic views at baseline (B) and follow-up consultation (C) of a 0.45-mm-thick melanoma located on the abdomen of a 57-year-old man. The lesion was excised 4½ years after the baseline consultation because of slight changes detected in side-by-side comparison of dermoscopic images. After such long-term follow-up, the lesion exhibits only a minor increase in size.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

3 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Make the Diagnosis: Melanoma