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Dermoscopic Findings in Laugier-Hunziker Syndrome FREE

Gulsum Gencoglan, MD; Bengu Gerceker-Turk, MD; Isil Kilinc-Karaarslan, MD; Taner Akalin, MD; Fezal Ozdemir, MD
[+] Author Affiliations

Author Affiliations: Departments of Dermatology (Drs Gencoglan, Gerceker-Turk, Kilinc-Karaarslan, and Ozdemir) and Pathology (Dr Akalin), Ege University, Bornova, Izmir, Turkey.


Arch Dermatol. 2007;143(5):631-633. doi:10.1001/archderm.143.5.631.
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Background  Laugier-Hunziker syndrome (LHS) is a rare, acquired mucocutaneous hyperpigmentation often associated with longitudinal melanonychia. The clinical behavior of mucocutaneous pigmented lesions ranges from benign to highly malignant. Therefore, in most cases, the clinical diagnosis should be confirmed by further diagnostic methods. Dermoscopy is a noninvasive technique that has been used to make more accurate diagnoses of pigmented skin lesions. Nevertheless, to our knowledge, the dermoscopic features of the pigmented lesions in LHS have not been described previously. Herein, we report a case of LHS together with its dermoscopic features.

Observations  The clinical examination revealed macular hyperpigmentation on the oral and genital mucosa, conjunctiva, and palmoplantar region together with longitudinal melanonychia. Dermoscopic examination of mucosal lesions on the patient's lips and vulva revealed a parallel pattern. Longitudinal homogeneous pigmentation was observed on the toenails. The pigmented macules on the palms and the sole showed a parallel furrow pattern. A skin biopsy sample taken from the labial lesion was compatible with a diagnosis of mucosal melanosis.

Conclusions  By means of this case report, the dermoscopic features of the pigmented lesions in LHS are described for the first time, which facilitates diagnosis with a noninvasive technique. Future reports highlighting the dermoscopic features of this syndrome may simplify the diagnosis of LHS, which is thought to be underdiagnosed.

Figures in this Article

Laugier-Hunziker syndrome (LHS) is a rare, acquired disorder characterized by benign macular hyperpigmentation of the oral and genital mucosa, which is associated with longitudinal melanonychia in 50% to 60% of cases.1 Dermoscopic examination should be indicated for patients with LHS who have several pigmented lesions on the mucosa, nails, or skin. However, to our knowledge, this is the first description of the dermoscopic features of the lesions in LHS.

A 24-year-old female patient was referred to our dermoscopy unit because she had bluish-brown maculae on her lips (Figure 1A) and gingiva and pigmented papillae on her tongue (Figure 1B). In addition, a longitudinal hyperpigmented macule on the vulva extending from the labia minora to the labia majora (Figure 1C), an ill-defined hyperpigmented conjunctival macule (Figure 1D), 3 small pigmented macules on the palms and 1 on the sole, and linear melanonychia on the toenails were also observed. She had no medical history of receiving medication for, or family history of, pigmentation disorder or intestinal polyposis. Findings from the laboratory tests were within reference range, and the assessment of her gastrointestinal system included radiological examinations and a colonoscopy, the findings from which were also within reference range. Findings from the histological examination of the lesion on her lip revealed hyperpigmentation of basal keratinocytes. There were also perivascular melanin-laden macrophages in the papillary dermis (Figure 2A). Masson-Fontana staining was positive for melanin (Figure 2B), but staining with Prussian blue was negative for hemosiderin. Melanocytic proliferation was not detected immunohistochemically with S100 antibody. According to these findings, a diagnosis of LHS was made.

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Figure 1.

A 24-year-old female patient diagnosed as having Laugier-Hunziker syndrome. Note the bluish-brown pigmentation of the upper lip (A) and the tongue (B); longitudinal brownish pigmentation on the vulva (C); and an ill-defined conjunctival macule (D).

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Figure 2.

Hyperpigmentation of basal keratinocytes and melanophage population in the papillary dermis. A, Hematoxylin-eosin, original magnification ×100; B, highlighted hyperpigmentation with Masson-Fontana stain, original magnification ×100.

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Dermoscopic examination of mucosal lesions on the patient's lips and vulva revealed parallel patterns. On the lips, linear, streaklike brown pigmentation caused by the skin furrows and reliefs was associated with multiple brown dots of different sizes distributed regularly throughout the lesion (Figure 3A). The parallel pattern seen on the vulva was partially linear and partially curvilinear, with light- to dark-brown streaks following the cutaneous profile (Figure 3B). Homogeneous, brownish, regular bandlike pigmentations with indistinct borders were seen on 4 toenails (Figure 3C). The pigmented macules on the palms and on the sole showed a parallel furrow pattern (Figure 4).

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Figure 3.

Dermoscopic examination of mucosal lesions. A, Parallel furrow pattern with multiple brown dots on the lip. B, Parallel furrow pattern with linear and curvilinear streaks on the vulva. C, Homogeneous regular bandlike pigmentations with indistinct borders on the toenail; inset, melanonychia longitudinalis.

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Figure 4.

Parallel furrow pattern of pigmented macules, all characterized by linear pigmentation following the sulci of the surface skin markings. A and B, Single dotted-line variation (single dotted lines along the sulci) on the left palm; C, single-line variant (single line along the sulci) on the right palm; and D, single-line variant with homogeneous pigmentation in the background on the sole.

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In the case reported described herein, a parallel pattern was observed on the patient's lips and vulva. On the lips, it was accompanied by regularly distributed multiple brown dots without any other dermoscopic variable suggestive of a malignancy. To our knowledge, the presence of multiple dots has not been reported in the limited number of articles published on dermoscopic features of mucosal melanosis.2,3 The parallel pattern with multiple brown dots correlated histopathologically with melanin pigmentation of basal keratinocytes and dermal melanophages, and these dots would be an expected finding when a patient has a superficial pigmentary incontinence. On the vulva, the pigmentation observed on dermoscopy was seen as partially linear and partially curvilinear brown streaks following the cutaneous profile, and this observation was concordant with the characteristic features of benign genital melanosis as defined by Soyer et al.4

The longitudinal melanonychia in our patient revealed homogeneous brownish regular bands with indistinct borders, and the pigmented macules on the palms and the sole revealed a parallel furrow pattern on dermoscopy.

By means of this case, the dermoscopic features of LHS are described for the first time. Future reports will improve our perception of this rarely seen entity.

Correspondence: Isil Kilinc-Karaarslan, MD, Ege University, Department of Dermatology, 35100, Bornova, Izmir, Turkey (kilinci35@yahoo.com).

Financial Disclosure: None reported.

Accepted for Publication: September 26, 2006.

Author Contributions:Study concept and design: Gerceker-Turk, Kilinc-Karaarslan, and Ozdemir. Acquisition of data: Gencoglan, Gerceker-Turk, and Ozdemir. Analysis and interpretation of data: Gerceker-Turk, Akalin, and Ozdemir. Drafting of the manuscript: Gencoglan, Gerceker-Turk, Kilinc-Karaarslan, Akalin, and Ozdemir. Critical revision of the manuscript for important intellectual content: Ozdemir. Administrative, technical, and material support: Gerceker-Turk. Study supervision: Ozdemir.

Makhoul  ENAyoub  NMHelou  JFAbadjian  GA Familial Laugier-Hunziker syndrome. J Am Acad Dermatol 2003;49 ((suppl)) S143- S145
PubMed
Gaeta  GMSatriano  RABaroni  A Oral pigmented lesions. Clin Dermatol 2002;20286- 288
PubMed
Mannone  FDe Giorgi  VCattaneo  AMassi  DDe Magnis  ACarli  P Dermoscopic features of mucosal melanosis. Dermatol Surg 2004;301118- 1123
PubMed
Soyer  HPArgenziano  GRuocco  VChimenti  S Dermoscopy of pigmented skin lesions (part II). Eur J Dermatol 2001;11483- 498
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

A 24-year-old female patient diagnosed as having Laugier-Hunziker syndrome. Note the bluish-brown pigmentation of the upper lip (A) and the tongue (B); longitudinal brownish pigmentation on the vulva (C); and an ill-defined conjunctival macule (D).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Hyperpigmentation of basal keratinocytes and melanophage population in the papillary dermis. A, Hematoxylin-eosin, original magnification ×100; B, highlighted hyperpigmentation with Masson-Fontana stain, original magnification ×100.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Dermoscopic examination of mucosal lesions. A, Parallel furrow pattern with multiple brown dots on the lip. B, Parallel furrow pattern with linear and curvilinear streaks on the vulva. C, Homogeneous regular bandlike pigmentations with indistinct borders on the toenail; inset, melanonychia longitudinalis.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

Parallel furrow pattern of pigmented macules, all characterized by linear pigmentation following the sulci of the surface skin markings. A and B, Single dotted-line variation (single dotted lines along the sulci) on the left palm; C, single-line variant (single line along the sulci) on the right palm; and D, single-line variant with homogeneous pigmentation in the background on the sole.

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Tables

References

Makhoul  ENAyoub  NMHelou  JFAbadjian  GA Familial Laugier-Hunziker syndrome. J Am Acad Dermatol 2003;49 ((suppl)) S143- S145
PubMed
Gaeta  GMSatriano  RABaroni  A Oral pigmented lesions. Clin Dermatol 2002;20286- 288
PubMed
Mannone  FDe Giorgi  VCattaneo  AMassi  DDe Magnis  ACarli  P Dermoscopic features of mucosal melanosis. Dermatol Surg 2004;301118- 1123
PubMed
Soyer  HPArgenziano  GRuocco  VChimenti  S Dermoscopy of pigmented skin lesions (part II). Eur J Dermatol 2001;11483- 498
PubMed

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