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Correspondence |

Adult Disseminated Primary Papular Xanthoma Treated With Doxycycline

Jesús Bastida, MD; Rafael Camacho-Galán, MD; M. Aser Armesto-Fernández, MD; Carlos Díaz-Cascajo, MD
Arch Dermatol. 2007;143(5):659-675. doi:10.1001/archderm.143.5.667.
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Adult disseminated primary papular xanthoma (pPX) is a rare histiocytic proliferation of dermal dendrocyte origin in the spectrum of non–Langerhans cell histiocytosis. Adult disseminated pPX shows a chronic course, and no effective treatment is known. Herein we describe a woman with cutaneous lesions associated with pPX that showed complete regression after treatment with oral doxycycline.

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Figure 1.

Our patient had progressive appearance of hundreds of asymptomatic papules. A, Yellowish dome-shaped lesions on the back. B, Anetodermic scars after complete resolution of the lesions.

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Figure 2.

Histopathologic findings of our patient's lesions. A, Dermal histiocytic aggregates with scarce inflammatory infiltrate (hematoxylin-eosin, original magnification ×40). B, Foamy histiocytes and Touton cells (hematoxylin-eosin, original magnification ×400). C, Histiocytic cells are factor XIIIa positive (immunoperoxidase stain, original magnification ×100).

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