We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Adult Disseminated Primary Papular Xanthoma Treated With Doxycycline

Jesús Bastida, MD; Rafael Camacho-Galán, MD; M. Aser Armesto-Fernández, MD; Carlos Díaz-Cascajo, MD
Arch Dermatol. 2007;143(5):659-675. doi:10.1001/archderm.143.5.667.
Text Size: A A A
Published online


Adult disseminated primary papular xanthoma (pPX) is a rare histiocytic proliferation of dermal dendrocyte origin in the spectrum of non–Langerhans cell histiocytosis. Adult disseminated pPX shows a chronic course, and no effective treatment is known. Herein we describe a woman with cutaneous lesions associated with pPX that showed complete regression after treatment with oral doxycycline.

Hu  CHWinkelmann  RK Unusual normolipidemic cutaneous xanthomatosis: a comparison of two cases illustrating the differential diagnosis. Acta Derm Venereol 1977;57421- 429
Beurey  JLamaze  MWeber  MDelrous  JLKremer  BChaulieu  Y Xanthoma disseminatum (syndrome de Montgomery). Ann Dermatol Venereol 1979;106353- 359
Thomas  RHMiller  NEPayne  CMEBlack  MM Papular xanthoma associated with primary dysbetalipoproteinaemia. J R Soc Med 1982;75906- 908
Sanchez  RLRaimer  SSPeltier  FSwedo  J Papular xanthoma: a clinical, histologic and ultrastructural study. Arch Dermatol 1985;121626- 631
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.1985.01660050078019]]
Bundino  SZina  AMAloi  F Papular xanthoma: clinical, histological and ultrastructural study. Dermatologica 1988;177382- 385
PubMed Link to Article[[XSLOpenURL/10.1159/000248611]]
Pfennigsdorf  SLieb  WE Papulöse Xanthome der lider. Klin Monatsbl Augenheilkd 1997;210113- 115
PubMed Link to Article[[XSLOpenURL/10.1055/s-2008-1035027]]
Caputo  RPassoni  ECavicchini  S Papular xanthoma associated with angiokeratoma of Fordyce: considerations on the nosography of this rare non-Langerhans cell histiocytomatosis. Dermatology 2003;206165- 168
PubMed Link to Article[[XSLOpenURL/10.1159/000068471]]
Breier  FZelger  BReiter  HGschnait  FZelger  BWH Papular xanthoma: a clinicopathological study of 10 cases. J Cutan Pathol 2002;29200- 206
PubMed Link to Article[[XSLOpenURL/10.1034/j.1600-0560.2002.290402.x]]
Weinberg  JM The anti-inflammatory effects of tetracyclines. Cutis 2005;75 ((4) (suppl)) 6- 11
Sandler  CNurmi  KLindstedt  KA  et al.  Chemically modified tetracyclines induce apoptosis in cultured mast cells. Int Immunopharmacol 2005;51611- 1621
PubMed Link to Article[[XSLOpenURL/10.1016/j.intimp.2005.04.013]]
Chu  AC Histiocytoses. Burns  TBreathnach  SCox  NGriffiths  Ceds.Rook's Textbook of Dermatology. 3 Malden, Mass Blackwell Publishing2004;52.1- 52.23
Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.

Our patient had progressive appearance of hundreds of asymptomatic papules. A, Yellowish dome-shaped lesions on the back. B, Anetodermic scars after complete resolution of the lesions.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Histopathologic findings of our patient's lesions. A, Dermal histiocytic aggregates with scarce inflammatory infiltrate (hematoxylin-eosin, original magnification ×40). B, Foamy histiocytes and Touton cells (hematoxylin-eosin, original magnification ×400). C, Histiocytic cells are factor XIIIa positive (immunoperoxidase stain, original magnification ×100).

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

5 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections