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Correspondence |

Involution: The Natural Evolution of Pigmented Spitz and Reed Nevi?

Giuseppe Argenziano, MD; Iris Zalaudek, MD; Gerardo Ferrara, MD; Antonio Lorenzoni, MD; H. Peter Soyer, MD
Arch Dermatol. 2007;143(4):543-551. doi:10.1001/archderm.143.4.549.
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The natural history of melanocytic nevi is poorly understood owing to the lack of follow-up studies investigating their long-term evolution. Current epidemiologic data report that the number of pigmented Spitz and Reed nevi (PSRN) peaks during the first or second decades of life, while they are rarely seen by the seventh to ninth decades.1 An explanation might be their gradual involution, but this assumption has still to be proven. We report herein 2 cases of pigmented lesions with typical clinical and dermoscopic features of PSRN that showed gradual involution at the follow-up examinations.

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Figure 1.

Evolution of a small pigmented lesion over 3 years. A, Dermoscopically, the lesion is characterized by a starburst pattern with pigmented streaks regularly distributed at the periphery. B, After 3 years, an almost complete involution of the lesions has occurred, with only remnants of light-brown pigmentation visible.

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Figure 2.

Evolution of a symmetric pigmented papule of the left lower leg over 6 months. A, Clinical view. B, Dermoscopically, striking brown to black globules of varying size are visible. C, After 1 month, a substantial decrease in the number and size of brown globules is apparent. D, After 6 months, the globules are not discernible anymore, and only remnants of light-brown to gray pigmentation are still visible.

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