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Correspondence |

Acute Generalized Exanthematous Pustulosis Caused by Illicit Street Drugs?

Linh K. Lu, MD, PhD; Whitney A. High, MD
Arch Dermatol. 2007;143(3):423-431. doi:10.1001/archderm.143.3.430.
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Acute generalized exanthematous pustulosis (AGEP) occurs as a hypersensitivity reaction to ingested drugs in over 90% of cases.1 We report a case of AGEP associated with recreational drug use—namely, cocaine or marijuana.

Beltraminelli  HSLerch  MArnold  A  et al.  Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature. Br J Dermatol 2005;152780- 783
PubMed Link to Article[[XSLOpenURL/10.1111/bjd.2005.152.issue-4]]
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PubMed Link to Article[[XSLOpenURL/10.1001/archderm.1991.01680080069004]]
Wolkenstein  PChosidow  OFlecher  ML  et al.  Patch testing in severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996;35234- 236
PubMed Link to Article[[XSLOpenURL/10.1111/cod.1996.35.issue-4]]
Kardaun  SHde Monchy  JG Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test. J Am Acad Dermatol 2006;55S21- S23
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaad.2006.02.032]]
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Figure 1.

Small, nonfollicular pustules on an erythematous base located on the abdomen of a 19-year-old woman. Inset shows a closer view of the pustules.

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Figure 2.

Subcorneal blister with neutrophils and epidermal spongiosis overlying a superficial perivascular lymphocytic infiltrate with numerous dermal eosinophils (arrowheads) (hematoxylin-eosin, original magnification ×200).

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