There is no universally accepted treatment for PG and no therapy has been subjected to a controlled clinical trial. In mild disease, therapy consists of local wound care and topical or intralesional corticosteroids. For more severe disease, systemic agents are necessary. These include steroid-sparing agents such as sulfasalazine, dapsone, clofazimine, and other antibiotics. Systemic corticosteroids are often effective, but large doses are required leading to serious long-term adverse effects. Other immunosuppressive agents such as cyclosporine, infliximab, etanercept, tacrolimus, mycophenolate mofetil, methotrexate, azathioprine, mercaptopurine, and cyclophosphamide have been reported to be successful in individual case reports and small case series. However, they too are associated with significant toxic effects.