0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
skINsight |

Dermoscopy Insights Into Nevogenesis:  “Abtropfung” vs “Hochsteigerung”

Iris Zalaudek, MD; Gerardo Ferrara, MD; Giuseppe Argenziano, MD
Arch Dermatol. 2007;143(2):284. doi:10.1001/archderm.143.2.284.
Text Size: A A A
Published online

Extract

Two concepts, the “Abtropfung” and the “Hochsteigerung,” have been used to explain the natural evolution of melanocytic nevi. The nevi in Figure 1 and Figure 2 are located on the respective backs of a 25- and a 20-year-old woman. By dermoscopy, the former first exhibited a central bluish pigmentation indicating pigmented cells in the papillary dermis (Figure 1A), while a significant color change toward brown occurred after 8 months (Figure 1B), reflecting the presence of pigment at the dermoepidermal junction. The nevus in Figure 2 reveals an opposite trend after 1 year of follow-up, with significant change of the color from brown (Figure 2A) to blue (Figure 2B). Whether this is caused by a real movement of cells (upward or downward) or by a different activation and/or maturation level of melanin-producing melanocytes remains speculative. Based on our observation, currently both concepts or the concept of “nevus activation” seem to be plausible to explain some steps in the evolution process of melanocytic nevi.

Figures in this Article

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 8

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();