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On the Horizon |

The Role of IgE Anti–Basement Membrane Zone Autoantibodies in Bullous Pemphigoid

David T. Woodley, MD
Arch Dermatol. 2007;143(2):249-250. doi:10.1001/archderm.143.2.249.
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REFERENCES
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PubMed Link to Article[[XSLOpenURL/10.1172/JCI113803]]
Diaz  LARatrie  H  IIISaunders  WS  et al.  Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera: immunolocalization of this protein to the hemidesmosome. J Clin Invest 1990;861088- 1094
PubMed Link to Article[[XSLOpenURL/10.1172/JCI114812]]
Giudice  GJEmery  DJDiaz  LA Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol 1992;99243- 250
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Liu  ZDiaz  LATroy  JL  et al.  A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J Clin Invest 1993;922480- 2488
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Arbesman  CEWypych  JIReisman  REBeutner  EH IgE levels in sera of patients with pemphigus or bullous pemphigoid. Arch Dermatol 1974;110378- 381
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.1974.01630090016003]]
Delaporte  EDubost-Brama  AGhohestani  R  et al.  IgE autoantibodies directed against the major bullous pemphigoid antigen in patients with a severe form of pemphigoid. J Immunol 1996;1573642- 3647
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Christophoridis  SBudinger  LBorradori  LHunziker  TMerk  HFHertl  M IgG, IgA and IgE autoantibodies against the ectodomain of BP180 in patients with bullous and cicatricial pemphigoid and linear IgA bullous dermatosis. Br J Dermatol 2000;143349- 355
PubMed Link to Article[[XSLOpenURL/10.1046/j.1365-2133.2000.03661.x]]
Dopp  RSchmidt  EChimanovitch  ILeverkus  MBrocker  EBZillikens  D IgG4 and IgE are the major immunoglobulins targeting the NC16A domain of BP180 in bullous pemphigoid: serum levels of these immunoglobulins reflect disease activity. J Am Acad Dermatol 2000;42577- 583
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Dimson  OGGiudice  GJFu  C-LWarren  SJJanson  MMFairley  JA Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid. J Invest Dermatol 2003;120784- 788
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Bowszyc-Dmochowska  MSilny  WDmochowski  M Detection of IgG4 deposits using a single-step direct immunofluorescence on natrium chloride-separated skin and elevated levels of serum total IgE in active bullous pemphigoid. J Invest Dermatol 2000;114804a
Fairley  JAFu  CLGiudice  GJ Mapping the binding sites of BP180 IgE autoantibodies in bullous pemphigoid. J Invest Dermatol 2005;125467- 472
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Dvorak  AMMihm  MC  JrOsage  JEKwan  THAusten  KFWintroub  BU Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient. J Invest Dermatol 1982;7891- 101
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Fairley  JABurnett  CTFu  CLFleming  MGGiudice  GJ Injection of bullous pemphigoid (BP) IgE autoantibodies into human skin grafted to nu/nu mice replicates the urticarial stage of BP. J Invest Dermatol 2005;124A13
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