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Correspondence |

Neurovascular Instability Syndrome: A Unifying Term to Describe the Coexistence of Temperature-Related Vascular Disorders in Affected Patients

Rosalyn George, MD; Gregory J. Fulchiero Jr, MD, MSBioEng; James G. Marks Jr, MD; Jennie T. Clarke, MD
Arch Dermatol. 2007;143(2):264-276. doi:10.1001/archderm.143.2.274.
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Temperature-related vascular disorders including pernio, erythromelalgia, and Raynaud phenomenon present a diagnostic and therapeutic challenge. We describe the unusual cooccurrence of perniosis and erythromelalgia. Although these conditions are aggravated by disparate environmental conditions, their coexistence may help to elucidate their pathophysiologic characteristics.

Crowson  ANMagro  CM Idiopathic perniosis and its mimics: a clinical and histological study of 38 cases. Hum Pathol 1997;28478- 484
PubMed Link to Article[[XSLOpenURL/10.1016/S0046-8177(97)90038-1]]
Michiels  JJte Morsche  RHJansen  JBDrenth  JP Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7. Arch Neurol 2005;621587- 1590
PubMed Link to Article[[XSLOpenURL/10.1001/archneur.62.10.1587]]
Davis  MDSandroni  PRooke  TWLow  PA Erythromelalgia: vasculopathy, neuropathy, or both? a prospective study of vascular and neurophysiologic studies in erythromelalgia. Arch Dermatol 2003;1391337- 1343
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.139.10.1337]]
Berlin  ALPehr  K Coexistence of erythromelalgia and Raynaud's phenomenon. J Am Acad Dermatol 2004;50456- 460
PubMed Link to Article[[XSLOpenURL/10.1016/S0190-9622(03)02121-2]]
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