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Correspondence |

Onset of Psoriasis During Treatment With TNF-α Antagonists: A Report of 3 Cases

Ravi Ubriani, MD; Abby S. Van Voorhees, MD
Arch Dermatol. 2007;143(2):264-276. doi:10.1001/archderm.143.2.270.
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Human recombinant soluble tumor necrosis factor (TNF) α receptors (etanercept) and monoclonal antibodies to TNF-α (infliximab and adalimumab) have been used successfully to treat a wide range of inflammatory conditions, including psoriasis. We report 1 case of plaque-type psoriasis and 2 cases of pustular psoriasis that developed in patients with no history of psoriasis who were being treated with TNF-α antagonists.

Sfikakis  PPIliopoulos  ADalmau  JRicart  ERoe  EAlomar  A Psoriasis induced by anti-tumor necrosis factor therapy: a paradoxical adverse reaction. Arthritis Rheum 2005;522513- 2518
PubMed Link to Article[[XSLOpenURL/10.1002/(ISSN)1529-0131]]
Kary  SWorm  MAudring  H  et al.  New onset or exacerbation of psoriatic skin lesions in patients with definite rheumatoid arthritis receiving tumour necrosis factor alpha antagonists. Ann Rheum Dis 2006;65405- 407
PubMed Link to Article[[XSLOpenURL/10.1136/ard.2005.037424]]
Peramiquel  LPuig  LWorm  M  et al.  Onset of flexural psoriasis during infliximab treatment for Crohn's disease. Clin Exp Dermatol 2005;30713- 714
PubMed Link to Article[[XSLOpenURL/10.1111/ced.2005.30.issue-6]]
Thurber  MFeasel  AStroehlein  JHymes  SR Pustular psoriasis induced by infliximab. J Drugs Dermatol 2004;3439- 440
Verea  MMDel Pozo  JYebra-Pimentel  MTPorta  AFonseca  E Psoriasiform eruption induced by infliximab. Ann Pharmacother 2004;3854- 57
PubMed Link to Article[[XSLOpenURL/10.1345/aph.1C477]]
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Figure 1.

Erythematous plaques suggestive of psoriasis or a drug eruption.

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Figure 2.

Regular elongation of rete ridges associated with thinning suprapapillary plates, a variably attenuated granular cell layer, and ectatic papillary blood vessels.

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