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The Cutting Edge |

Cinacalcet for the Treatment of Calciphylaxis FREE

Maria R. Robinson, MD; Joshua J. Augustine, MD; Neil J. Korman, MD, PhD
[+] Author Affiliations

Section Editor: George J. Hruza, MD
Assistant Section Editor: Michael P. Heffernan, MD
Assistant Section Editor: Summer R. Youker, MD

More Author Information
Arch Dermatol. 2007;143(2):152-154. doi:10.1001/archderm.143.2.152.
Text Size: A A A
Published online

Calciphylaxis is characterized by cutaneous ischemia and necrosis and is associated with a very high mortality rate. It usually affects patients who are undergoing dialysis or who have received a kidney transplant. There is no optimal treatment, but parathyroidectomy has shown some benefit. We report herein a case of a patient with calciphylaxis and secondary hyperparathyroidism who was successfully treated with cinacalcet hydrochloride, a calcimimetic.

A 62-year-old man was admitted to the hospital for gastrointestinal bleeding and was found to have an elevated international normalized ratio. The patient had a medical history of chronic nephrolithiasis from long-standing Crohn disease that required an ileostomy and end-stage renal disease that had resulted in a kidney transplant 2 years prior to presentation. During his hospitalization, the dermatology department was consulted because the patient had painful bilateral thigh ulcers, which had developed 4 months prior to admission.

On initial examination, the patient had a 3.0 × 4.0-cm ulcer with eschar and surrounding induration and violaceous discoloration on his right thigh. On his left thigh, there was a 2.5-cm × 4.0-mm linear hemorrhagic crust. In addition, he had violaceous discoloration in a livedo reticularis pattern over his lower extremities bilaterally. Laboratory evaluation on admission included the following findings: his calcium level was 7.9 mg/dL (2.0 mmol/L); phosphorus level, 5.5 mg/dL (1.8 mmol/L); albumin level, 3.3 g/dL; urea nitrogen level, 39 mg/dL (13.9 mmol/L); creatinine level, 4.0 mg/dL (305.0 μmol/L); intact parathyroid hormone level, 1080 pg/mL (reference range, 7-53 pg/mL); 25-hydroxyvitamin D level, 10.0 ng/mL (25.0 nmol/L) (reference range, 20-57 ng/mL [49.9-142.3 ng/mL]); and 1,25-dihydroxyvitamin D level, 11.1 pg/mL (28.9 pmol/L) (reference range, 15.9-55.6 pg/ml [41.3-144.6 pmol/L]). The calcium-phosphorus product was 43.5 mg/dL. Findings from an excisional biopsy of the right thigh ulcer showed focal ulceration with fibrinoid and hemorrhagic exudate. There were also numerous small vessel thrombi and deposits of calcium present within the deep blood vessel walls. These histologic findings indicated a diagnosis of calciphylaxis.

The patient was treated with silver sulfadiazine cream twice a day with aggressive wound care for the ulcers, vitamin D therapy, and phosphorus binders. The patient's hypocalcemia and hyperphosphatemia improved with therapy. Although his persistently elevated parathyroid hormone level improved, there was no improvement in his wounds. Parathyroid imaging was negative for parathyroid adenoma. His elevated international normalized ratio was corrected with vitamin K supplementation, and he was discharged from the hospital.

One month later, his wounds had increased in size, with the right thigh ulcer increasing to 5 × 9 cm and the left thigh ulcer to 3 × 6 cm (Figure 1). On his posterior calves bilaterally, there were tender, erythematous, and indurated plaques ranging in size from 1 to 3 cm.

Place holder to copy figure label and caption
Figure 1.

Large ulcer on the left thigh with eschar and surrounding erythema and induration before treatment with cinacalcet hydrochloride.

Graphic Jump Location

Calciphylaxis is characterized by progressive vascular calcium deposition and cutaneous ischemia and necrosis and usually affects patients with end-stage renal disease who are undergoing hemodialysis or have received a kidney transplant. Although there is no optimal treatment for calciphylaxis, there have been several reports of beneficial treatment using different modalities. These include low-dose tissue plasminogen activator,1 parathyroidectomy,24 hyperbaric oxygen,5,6 wound debridement,7 intravenous sodium thiosulfate,8 low-molecular-weight heparin,9 increased frequency of hemodialysis,10 and using a zero-calcium dialysate.11

Our patient presented with clinical and histopathologic evidence of calciphylaxis. He also had secondary hyperparathyroidism induced by his end-stage renal disease. His parathyroid hormone levels were as high as 1080 pg/mL. He was considered to be a high-risk surgical candidate for parathyroidectomy, and continued wound care did not halt the progression of disease.

Parathyroidectomy prolongs survival in some patients with calciphylaxis,24 but its role is still controversial.12,13 Parathyroidectomy both lowers parathyroid hormone levels and helps restore normal calcium and phosphorous homeostasis, helping to reduce known risk factors for calciphylaxis.14 Because this patient was a high-risk surgical candidate, medical treatment with cinacalcet, a calcimimetic that has lowered parathyroid levels in patients receiving hemodialysis,15 was started. The patient received a daily dose of 30 mg of cinacalcet hydrochloride.

Several weeks after the initiation of therapy with cinacalcet, the patient reported less pain associated with the ulcers, and his parathyroid hormone level continued to decline (Table). On physical examination, the right thigh wound showed dramatic improvement with re-epithelialization of the ulcer, and the left thigh wound also began to heal. Five months after he began treatment with cinacalcet, both ulcers continued to heal and the patient noted symptomatic improvement (Figure 2). During this time, the patient did develop 4 smaller 1- to 3-cm ulcers over his lower extremities. Three of these wounds healed, and the fourth did not become larger. After 5 months of treatment, the dosage of cinacalcet hydrochloride was increased to 60 mg/d, and his parathyroid hormone level continued to decline. His last measured value was 147 pg/mL (Table).

Place holder to copy figure label and caption
Figure 2.

Left thigh ulcer after 5 months of treatment with cinacalcet hydrochloride.

Graphic Jump Location
Table Graphic Jump LocationTable. Patient Laboratory Values Over the Course of Several Months*

The prevalence of calciphylaxis has been estimated to be approximately 4% in patients who are undergoing hemodialysis,16 and mortality estimates are as high as 87%.9 Prognosis has been shown to vary with lesion distribution, with survival rates ranging from 25% for proximal lesions and 75% for distal lesions.2 The pathogenesis of calciphylaxis (also referred to as uremic small-artery disease with medial calcification and intimal hyperplasia, uremic small-vessel disease, uremic gangrene syndrome, and calcific uremic arteriolopathy) is incompletely understood. Several risk factors have been identified, including secondary hyperparathyroidism,17 increased serum phosphate and calcium × phosphate product, female sex, diabetes mellitus,14 and protein C deficiency.18

Parathyroid hormone, the main regulator of calcium homeostasis, is affected by calcium, phosphorous, and 1,25-dihydroxyvitamin D3 levels. In patients with renal failure, there is an impaired ability to clear phosphorous and an impaired synthesis of 1,25-dihydroxyvitamin D3, which result in hyperphosphatemia and decreased calcium absorption. These elements contribute to the development of secondary hyperparathyroidism, which is common in patients undergoing hemodialysis.19,20 In addition, a deficiency in vitamin D can exacerbate secondary hyperparathyroidism. The medical treatment of secondary hyperparathyroidism includes control of hyperphosphatemia and therapy with calcitriol.21 Levels of parathyroid hormone are not uniformly elevated in patients with calciphylaxis, and some physicians have recommended parathyroidectomy only for patients with intractable secondary hyperparathyroidism uncontrolled by medical means.21,22

To treat the patient's secondary hyperparathyroidism with very high levels of parathyroid hormone, therapy with cinacalcet, a class II calcimimetic that targets the calcium-sensing receptor of the parathyroid gland chief cells, was started. Cinacalcet induces conformational change in the calcium receptor, thereby increasing its sensitivity to circulating calcium.23 Cinacalcet has been shown both to lower parathyroid hormone levels and to improve calcium-phosphorous homeostasis in patients receiving hemodialysis in randomized, double-blind, placebo-controlled trials.15 It is indicated for both the treatment of secondary hyperparathyroidism in patients receiving hemodialysis and the treatment of hypercalcemia in patients with parathyroid carcinoma.

Cinacalcet is generally well tolerated, and nausea and vomiting are the most frequent adverse events identified. Hypocalcemia also occurs in approximately 5% of patients receiving cinacalcet (vs <1% in placebo group; P<.001).15 Hypocalcemia is rarely associated with symptoms and is treated by changing dosages of calcium-containing phosphate-binding agents or vitamin D sterols.15 Calcium levels should be closely monitored during therapy with cinacalcet.

Results in our patient demonstrated that cinacalcet may be a promising new approach to medically treat patients with calciphylaxis and secondary hyperparathyroidism. In addition to lowering the parathyroid hormone level, levels of calcium and phosphorous are also stabilized, which helps to correct potential risk factors that may be involved in the pathogenesis of calciphylaxis.

Submissions

Clinicians, residents, and fellows are invited to submit cases of challenges in management and therapeutics to this section. Cases should follow the established pattern. Manuscripts should be prepared double-spaced with right margins nonjustified. Pages should be numbered consecutively with the title page separated from the text (see Instructions for Authors for information about preparation of the title page). Clinical photographs, photomicrographs, and illustrations must be sharply focused and submitted as separate JPG files with each file numbered with the figure number. Material must be accompanied by the required copyright transfer statement (see authorship form [http://archderm.ama-assn.org/misc/auinst_crit.pdf]). Preliminary inquiries regarding submissions for this feature may be submitted to George J. Hruza, MD (ghruza@aol.com). Manuscripts should be submitted via our online manuscript submission and review system (http://manuscripts.archdermatol.com).

Correspondence: Neil J. Korman, MD, PhD, Department of Dermatology, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 (neil.korman@uhhs.com).

Financial Disclosure: None reported.

Accepted for Publication: May 25, 2006.

Author Contributions:Study concept and design: Korman. Acquisition of data: Robinson. Analysis and interpretation of data: Robinson, Augustine, and Korman. Drafting of the manuscript: Robinson. Critical revision of the manuscript for important intellectual content: Augustine and Korman. Study supervision: Augustine and Korman.

Sewell  LDWeenig  RHDavis  MDDavis  MDMcEvoy  MTPittelkow  MR Low-dose tissue plasminogen activator for calciphylaxis. Arch Dermatol 2004;1401045- 1048
PubMed
Hafner  JKeusch  GWahl  C  et al.  Uremic small-artery disease with medial calcification and intimal hyperplasia (so-called calciphylaxis): a complication of chronic renal failure and benefit from parathyroidectomy. J Am Acad Dermatol 1995;33954- 962
PubMed
Girotto  JAHarmon  JWRatner  LENicol  TLWong  LChen  H Parathyroidectomy promotes wound healing and prolongs survival in patients with calciphylaxis from secondary hyperparathyroidism. Surgery 2001;130645- 651
PubMed
Arch-Ferrer  JEBeenken  SWRue  LWBland  KIDiethelm  AG Therapy for calciphylaxis: an outcome analysis. Surgery 2003;134941- 945
PubMed
Vassa  NTwardowski  ZJCampbell  J Hyperbaric oxygen therapy in calciphylaxis-induced skin necrosis in a peritoneal dialysis patient. Am J Kidney Dis 1994;23878- 881
PubMed
Podymow  TWherrett  CBurns  KD Hyperbaric oxygen in the treatment of calciphylaxis: a case series. Nephrol Dial Transplant 2001;162176- 2180
PubMed
Kang  ASMcCarthy  JTRowland  CFarley  DRVan Heerden  JA Is calciphylaxis best treated surgically or medically? Surgery 2000;128967- 972
PubMed
Cicone  JSPetronis  JBEmbert  CDSpector  DA Successful treatment of calciphylaxis with intravenous sodium thiosulfate. Am J Kidney Dis 2004;431104- 1108
PubMed
Coates  TKirkland  GSDymock  RB  et al.  Cutaneous necrosis from calcific uremic arteriolopathy. Am J Kidney Dis 1998;32384- 391
PubMed
Russell  RBrookshire  MAZekonis  MMoe  SM Distal calcific uremic arteriolopathy in a hemodialysis patient responds to lowering of Ca × P product and aggressive wound care. Clin Nephrol 2002;58238- 243
PubMed
Llach  F The evolving pattern of calciphylaxis: therapeutic considerations. Nephrol Dial Transplant 2001;16448- 451
PubMed
Chan  YLMahony  JFTurner  JJPosen  S The vascular lesions associated with skin necrosis in renal disease. Br J Dermatol 1983;10985- 95
PubMed
Roe  SMGraham  LDBrock  WBBarker  DE Calciphylaxis: early recognition and management. Am Surg 1994;6081- 86
PubMed
Fine  AZacharias  J Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int 2002;612210- 2217
PubMed
Block  GAMartin  KJde Francisco  AL  et al.  Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 2004;3501516- 1525
PubMed
Angelis  MWong  LLMyers  SAWong  LM Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery 1997;1221083- 1090
PubMed
Gipstein  RMCoburn  JWAdams  DA  et al.  Calciphylaxis in man. Arch Intern Med 1976;1361273- 1280
PubMed
Mehta  RLScott  GSloand  JAFrancis  CW Skin necrosis associated with acquired protein C deficiency in patients with renal failure and calciphylaxis. Am J Med 1990;88252- 257
PubMed
Salem  MM Hyperparathyroidism in the hemodialysis population: a survey of 612 patients. Am J Kidney Dis 1997;29862- 865
PubMed
Owda  AElhwairis  HNarra  STowery  HOsama  S Secondary hyperparathyroidism in chronic hemodialysis patients: prevalence and race. Ren Fail 2003;25595- 602
PubMed
Yudd  MLlach  F Current medical management of secondary hyperparathyroidism. Am J Med Sci 2000;320100- 106
PubMed
Don  BRChin  AI A strategy for the treatment of calcific uremic arteriolopathy (calciphylaxis) employing a combination of therapies. Clin Nephrol 2003;59463- 470
PubMed
Nemeth  EFHeaton  WHMiller  M  et al.  Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther 2004;308627- 635
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

Large ulcer on the left thigh with eschar and surrounding erythema and induration before treatment with cinacalcet hydrochloride.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Left thigh ulcer after 5 months of treatment with cinacalcet hydrochloride.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Patient Laboratory Values Over the Course of Several Months*

References

Sewell  LDWeenig  RHDavis  MDDavis  MDMcEvoy  MTPittelkow  MR Low-dose tissue plasminogen activator for calciphylaxis. Arch Dermatol 2004;1401045- 1048
PubMed
Hafner  JKeusch  GWahl  C  et al.  Uremic small-artery disease with medial calcification and intimal hyperplasia (so-called calciphylaxis): a complication of chronic renal failure and benefit from parathyroidectomy. J Am Acad Dermatol 1995;33954- 962
PubMed
Girotto  JAHarmon  JWRatner  LENicol  TLWong  LChen  H Parathyroidectomy promotes wound healing and prolongs survival in patients with calciphylaxis from secondary hyperparathyroidism. Surgery 2001;130645- 651
PubMed
Arch-Ferrer  JEBeenken  SWRue  LWBland  KIDiethelm  AG Therapy for calciphylaxis: an outcome analysis. Surgery 2003;134941- 945
PubMed
Vassa  NTwardowski  ZJCampbell  J Hyperbaric oxygen therapy in calciphylaxis-induced skin necrosis in a peritoneal dialysis patient. Am J Kidney Dis 1994;23878- 881
PubMed
Podymow  TWherrett  CBurns  KD Hyperbaric oxygen in the treatment of calciphylaxis: a case series. Nephrol Dial Transplant 2001;162176- 2180
PubMed
Kang  ASMcCarthy  JTRowland  CFarley  DRVan Heerden  JA Is calciphylaxis best treated surgically or medically? Surgery 2000;128967- 972
PubMed
Cicone  JSPetronis  JBEmbert  CDSpector  DA Successful treatment of calciphylaxis with intravenous sodium thiosulfate. Am J Kidney Dis 2004;431104- 1108
PubMed
Coates  TKirkland  GSDymock  RB  et al.  Cutaneous necrosis from calcific uremic arteriolopathy. Am J Kidney Dis 1998;32384- 391
PubMed
Russell  RBrookshire  MAZekonis  MMoe  SM Distal calcific uremic arteriolopathy in a hemodialysis patient responds to lowering of Ca × P product and aggressive wound care. Clin Nephrol 2002;58238- 243
PubMed
Llach  F The evolving pattern of calciphylaxis: therapeutic considerations. Nephrol Dial Transplant 2001;16448- 451
PubMed
Chan  YLMahony  JFTurner  JJPosen  S The vascular lesions associated with skin necrosis in renal disease. Br J Dermatol 1983;10985- 95
PubMed
Roe  SMGraham  LDBrock  WBBarker  DE Calciphylaxis: early recognition and management. Am Surg 1994;6081- 86
PubMed
Fine  AZacharias  J Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int 2002;612210- 2217
PubMed
Block  GAMartin  KJde Francisco  AL  et al.  Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 2004;3501516- 1525
PubMed
Angelis  MWong  LLMyers  SAWong  LM Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery 1997;1221083- 1090
PubMed
Gipstein  RMCoburn  JWAdams  DA  et al.  Calciphylaxis in man. Arch Intern Med 1976;1361273- 1280
PubMed
Mehta  RLScott  GSloand  JAFrancis  CW Skin necrosis associated with acquired protein C deficiency in patients with renal failure and calciphylaxis. Am J Med 1990;88252- 257
PubMed
Salem  MM Hyperparathyroidism in the hemodialysis population: a survey of 612 patients. Am J Kidney Dis 1997;29862- 865
PubMed
Owda  AElhwairis  HNarra  STowery  HOsama  S Secondary hyperparathyroidism in chronic hemodialysis patients: prevalence and race. Ren Fail 2003;25595- 602
PubMed
Yudd  MLlach  F Current medical management of secondary hyperparathyroidism. Am J Med Sci 2000;320100- 106
PubMed
Don  BRChin  AI A strategy for the treatment of calcific uremic arteriolopathy (calciphylaxis) employing a combination of therapies. Clin Nephrol 2003;59463- 470
PubMed
Nemeth  EFHeaton  WHMiller  M  et al.  Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther 2004;308627- 635
PubMed

Correspondence

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