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Correspondence |

Effect of Tacrolimus on Vitiligo in Absence of UV Radiation Exposure

Kabir Sardana, MD, DNB, MNAMS; Premanshu Bhushan, MD; Vijay Kumar Garg, MD, MNAMS
Arch Dermatol. 2007;143(1):115-126. doi:10.1001/archderm.143.1.119.
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We read with interest the article by Ostovari et al,1 who elegantly surmised that UV light is essential for tacrolimus to work. In our vitiligo clinic we have been studying the pattern of repigmentation of vitiligo with tacrolimus, the stability of this pigment, and the site variation for the last 2 years. We believe that there is sufficient evidence to show that tacrolimus monotherapy is useful to produce repigmentation.2

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Figure. Repigmentation of vitiligo-affected areas in 4 patients after treatment with tacrolimus alone. A, Diffuse repigmentation on the nipple of a 34-year-old woman (patient 1). B, Marginal repigmentation around the vulva and the anal meatus of a 9-year-old girl (patient 6). C, Diffuse repigmentation on the anterior aspect of the vulva of a 7-year-old girl (patient 2). D, Perifollicular pigmentation manifests as hyperpigmented dots on the vulva of a 7-year-old girl (patient 5), along with marginal repigmentation.

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