0
Observation |

Superficial Venous Thrombophlebitis as the Initial Manifestation of Hypereosinophilic Syndrome:  Study of the First 3 Cases FREE

Benjamin Terrier, MD; Anne-Marie Piette, MD; Delphine Kerob, MD; Florence Cordoliani, MD; Emmanuelle Tancrède, MD; Leila Hamidou, MD; Céleste Lebbé, MD, PhD; Olivier Blétry, MD, PhD; Jean-Emmanuel Kahn, MD
[+] Author Affiliations

Author Affiliations: Service de Médecine Interne, Hôpital Foch, Suresnes, France (Drs Terrier, Piette, Cordoliani, Tancrède, Blétry, and Kahn); and Service de Dermatologie (Drs Kerob and Lebbé) and Service de Radiologie (Dr Hamidou), Hôpital Saint-Louis, Paris, France.


Arch Dermatol. 2006;142(12):1606-1610. doi:10.1001/archderm.142.12.1606.
Text Size: A A A
Published online

Background  Superficial venous thrombophlebitis (SVT), often perceived as benign, can coexist with hypercoagulable states. Predisposing risk factors for SVT are similar to those observed for deep venous thrombosis. Association of eosinophilia with SVT is a rare situation that can reveal neoplasia, malignant blood disorders, or vasculitis, but it has never been described in hypereosinophilic syndrome (HES). We herein describe the clinical and biological features, outcome, and response to therapy of 3 patients with SVT associated with eosinophilia that revealed HES.

Observations  Superficial venous thrombophlebitis was the initial manifestation of HES in all 3 patients. The mean eosinophil count at diagnosis was 2.4 × 103/μL. All patients received corticosteroids and anticoagulants as the initial treatment, with marked improvement of SVT and return of the eosinophil count to reference limits. All patients experienced relapse and remained dependent on corticosteroid therapy. Two patients received interferon alfa with dramatic regression of SVT, allowing a decrease in the dose of corticosteroids.

Conclusions  We report, to our knowledge, the first 3 cases of SVT related to HES. Superficial venous thrombophlebitis was difficult to treat, with dependence on corticosteroid therapy and partial efficacy of anticoagulant and antiplatelet therapy. Interferon alfa was effective in preventing relapse of SVT related to HES. Mechanisms implied in this thrombogenesis are multiple and remain speculative.

Figures in this Article

Superficial venous thrombophlebitis (SVT) is usually a benign disorder that affects patients with venous insufficiency, but it can be the first manifestation of hypercoagulable states. Secondary causes of SVT must be sought, particularly when SVT is recurrent or multifocal or has spontaneous onset. Predisposing risk factors for SVT are similar to those observed for deep venous thrombosis, including varicose veins, the presence of acquired or inherited thrombophilia, postoperative states, pregnancy, malignancies, autoimmune diseases, Behçet disease, and Buerger disease. Among these various risk factors, eosinophilia has been reported during vasculitis, malignant blood disorders, and solid tumors. Hypereosinophilic syndrome (HES) has been associated with various thrombotic manifestations such as portal thrombosis,1 deep venous thrombosis,2,3 cerebral venous thrombosis,4 Budd-Chiari syndrome,5 hepatic veno-occlusive disease,6 or intracardiac thrombi,7 but SVT has never been described.

Hypereosinophilic syndrome is a rare hematological disorder with abnormal production of eosinophils by bone marrow and organ damage caused by the accumulation of eosinophils in tissues. Hypereosinophilic syndrome is usually defined by the criteria of Chusid et al,8 which include blood eosinophilia of more than 1.5 × 103/μL present for longer than 6 months, the absence of other known causes of eosinophilia, and the signs and symptoms of organ infiltration. Two main pathophysiological forms are distinguished. The myeloid variant of HES is a clonal myeloproliferative disorder characterized by frequent splenomegaly and possible evolution toward blast crisis. Cytogenetic abnormalities can be detected, such as those in the Fip1-like 1 platelet-derived growth factor receptor α (FIP1L1-PDGFRA) fusion gene, important in predicting the response to imatinib mesylate.9 In the lymphocytic variant of HES, hypereosinophilia occurs in response to interleukin 5 production by abnormal helper T type 2 cells (TH2 cells), which can be detected by analysis of the T-cell receptor gene and phenotyping of peripheral T cells, in the absence of other diseases.10 Cutaneous manifestations are common. The lymphoid variant usually follows an indolent course, but some patients can develop overt T-cell lymphomas. When the myeloid and lymphocytic variants are not clearly identified, the diagnosis of idiopathic HES may be considered.

The aim of this study was to describe the clinical and biological features, outcome, and response to therapy of patients with SVT related to HES.

We retrospectively analyzed recurrent SVT related to HES in 3 patients. All of the patients satisfied the criteria of Chusid et al.8 Superficial venous thrombophlebitis was confirmed by Doppler ultrasonography or biopsy findings in all patients. We found no evidence of acquired or inherited thrombophilia (ie, anticardiolipin antibodies and lupus anticoagulant, hyperhomocysteinemia, factor V Leiden, the prothrombin 20210A mutation, elevated factor VIII level, or antithrombin or protein C and S deficiencies). We excluded Behçet disease, neoplasia, and Buerger disease through medical history and follow-up, and there was no detectable glycosylphosphatidylinositol-deficient hematopoietic clone (for the diagnosis of paroxysmal nocturnal hemoglobinuria). The diagnosis of HES was considered in all 3 patients after exclusion of other known causes of eosinophilia, especially parasitic disease. In all patients, results of renal function and hepatic tests were within reference limits, and results of serum electrophoresis, chest radiography, echocardiography, eyeground examination, bacterial cultures, tests for rheumatoid factor, antinuclear antibodies, antineutrophil cytoplasmic antibodies, cryoglobulinemia, and parasitic feces, appropriate parasitic and viral (hepatitis C virus and human immunodeficiency virus) serologic tests, and bone marrow biopsy were negative. We evaluated for the presence of hypodense eosinophils by means of blood smear examination. The patients underwent screening for the FIP1L1-PDGFRA fusion gene by fluorescence in situ hybridization, analysis of the T-cell receptor gene to detect clonal rearrangement, and peripheral T-cell phenotyping. We noted clinical and biological features, outcome, and response to therapy. The patients were monitored for endomyocardial disease by electrocardiography and echocardiography, and for embolic phenomena by physical examination and Doppler ultrasonography. The mean duration of follow-up was 38 months (25, 59, and 30 months).

CASE 1

In June 2003, a 36-year-old man was referred for a 9-month history of recurrent SVT of all 4 limbs, confirmed by Doppler ultrasonography. He had no previous blood tests before admission. Veins in the lower limbs were erythematous and painful palpable cords (Figure 1). At diagnosis, the blood eosinophil level was 1.8 × 103/μL. The main results of the laboratory tests are summarized in the Table. Idiopathic HES was diagnosed. After treatment with prednisone (40 mg/d) and enoxaparin sodium, SVT completely regressed, and the eosinophil count was within reference limits. The prednisone dosage was tapered to 30 mg/d, and anticoagulant therapy was stopped in July 2003 after 1 month of treatment. Superficial venous thrombophlebitis and eosinophilia (0.6 × 103/μL) recurred in September 2003 at the prednisone dosage of 30 mg/d. A skin biopsy specimen from the thigh showed thrombosis of a hypodermal vein with a mild lymphocytic infiltrate (but no eosinophils) of the vessel wall. An increased dosage of prednisone given with colchicine and replacement of aspirin with fluindione led to temporary improvement of SVT. About 10 relapses occurred, half of them with eosinophilia (eg, eosinophilia at a level of 1.5 × 103/μL in June 2004 with STV relapse) while tapering the prednisone dosage to less than 20 mg/d. Fluindione and nadroparin calcium administration did not prevent SVT recurrences. In September 2004, interferon alfa (3 million units 3 times per week) resulted in dramatic regression of SVT, allowing for tapering of the prednisone dosage to less than 10 mg/d. Nadroparin was replaced by clopidogrel bisulfate. After 10 months of treatment with interferon alfa, no relapse of SVT occurred, and the blood eosinophil count remained below 1.0 × 103/μL. In May 2005, asthma and pulmonary micronodules occurred with moderate eosinophilia (0.6 × 103/μL). Findings for antineutrophil cytoplasmic antibodies and specific IgE anti–Aspergillus fumigatus remained negative, confirming the diagnosis of HES. Inhaled beclomethasone dipropionate therapy was added with a good efficacy for the asthma. The clinical and therapeutic time course is summarized in Figure 2.

Place holder to copy figure label and caption
Figure 1.

Superficial venous thrombophlebitis in the lower limb veins, seen as a reticulate array of erythematous and tender cords, in the patient in case 1. No livedo reticularis was noted on the physical examination.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Clinical and therapeutic time courses of the patients in the 3 cases. Arrows indicate relapses of superficial venous thrombophlebitis (SVT) or hypereosinophilic syndrome–related complications.

Graphic Jump Location
Table Graphic Jump LocationTable. Laboratory Tests of the Patients in the 3 Cases*
CASE 2

A 26-year-old man was referred for recurrent SVT of the lower limbs confirmed by examination of a skin biopsy specimen, which showed thrombosis of dermal vessels with moderate reactive perivascular lymphocytic infiltration. Physical examination results showed palpable erythematous veins and a livedo of the lower limbs, and prominent purpuric macules of the toes without cutaneous necrosis. He had a 6-month history of unexplained eosinophilia of 1.5 × 103/μL. The main results of the laboratory tests are summarized in the Table. No Doppler ultrasonography was performed. Idiopathic HES was diagnosed. Treatment with prednisone (30 mg/d) and fluindione resulted in improvement of SVT, livedo, and purpuric lesions, and improvement of the eosinophil count to reference limits. One relapse of SVT and livedo, with an eosinophil count within reference limits (0.4 × 103/μL), occurred after tapering of the prednisone dosage to 20 mg/d. Interferon alfa therapy (3 million U 3 times per week) was introduced and led to dramatic improvement of the cutaneous lesions. Fluindione was replaced by aspirin, and prednisone and interferon alfa dosages were tapered. No relapse of eosinophilia occurred during the 32 months of interferon alfa therapy associated with a stable dose of prednisone (5 mg/d). One month after stopping interferon therapy, livedo and SVT relapsed, associated with abdominal pain. The eosinophil count was 0.3 × 103/μL, but a gastric biopsy specimen showed marked infiltration by eosinophils (confirming the diagnosis of HES). Interferon alfa and prednisone were readministered with rapid improvement. No relapse occurred during an additional 7 months of follow-up. The clinical and therapeutic time course is summarized in Figure 2.

CASE 3

A 59-year-old man was referred for acrocyanosis. He had an 8-month history of hypereosinophilia (maximum level, 3.9 × 103/μL). Clinical examination showed hardened and painful erythematous veins, infiltrated erythematous plaques of the lower limbs, and flame-shaped subungual hemorrhage. Doppler ultrasonography showed bilateral SVT of the lower limbs without deep extension and arterial thrombosis of the upper limbs. A skin biopsy specimen of infiltrated lesions showed a dermal and subcutaneous infiltrate of eosinophils and vascular hyperplasia of a few vessels. The main results of the laboratory tests are summarized in the Table. Idiopathic HES was diagnosed. Treatment with a pulse of methylprednisolone hemisuccinate followed by oral prednisone (80 mg/d), fluindione, and aspirin resulted in improvement of arterial and venous thrombosis and improvement of the blood eosinophil count to within reference limits. Transient elevation of the eosinophil level (0.8 × 103/μL) occurred after tapering of the prednisone dosage to 5 mg/d, but was reversed with an increase of the dosage to 10 mg/d. No relapse occurred thereafter. The clinical and therapeutic time course is summarized in Figure 2.

Hypereosinophilic syndrome is a rare hematological disorder with abnormal production of eosinophils by bone marrow and organ damage caused by the accumulation of eosinophils in tissues. Organs and systems usually affected by HES include the heart, nervous system, skin, lungs, gastrointestinal tract, and, more rarely, blood vessels.3,11 The skin is one of the most frequently involved organs, and manifestations include angioedematous and urticarial lesions,12,13 erythematous pruritic papules, nodules,2,13 purpura, palmoplantar erythema,14 and, more exceptionally, microthrombi2 presenting as livedo reticularis, early retiform purpura or splinter hemorrhages, vasculitis, and cutaneous necrosis.1418 Peripheral arterial involvement occurs occasionally in HES.15,16,19 Although deep venous thrombosis has been reported, to our knowledge SVT has not been previously reported in HES.

Herein we describe 3 cases of SVT (recurrent in 2 patients and isolated in 1) related to HES. Their mean age was 40.3 (range, 26-59) years, and all were men. In our 3 cases, we did not find known causes of hypereosinophilia, in particular parasitic infection, allergic disease, or malignancy. Moreover, no systemic manifestation evocative of primary necrotizing vasculitis appeared during the follow-up. In 2 patients, there was no evidence of a myeloproliferative or lymphocytic variant of HES (ie, we did not detect the FIP1L1-PDGFRA fusion gene, cytogenetic abnormalities, or T-cell clonality), so the diagnosis of idiopathic HES was considered. In case 1, the detection of an isolated T-cell clonality may be consistent with the diagnosis of lymphocytic variant of HES. However, in the absence of phenotypically abnormal TH2 cells in peripheral blood, the diagnosis of idiopathic HES must be considered. Superficial venous thrombophlebitis was the initial manifestation of HES in all patients. All of the patients had other organ damage, including a dermal and subcutaneous infiltrate of eosinophils, eosinophilic gastritis, and pulmonary micronodules. None of them developed cardiac or neurological manifestations.

Several mechanisms have been proposed for vascular involvement in HES, including eosinophilic vasculitis, inhibition of anticoagulant activity of thrombomodulin by eosinophil cationic proteins,20 a direct toxic effect of eosinophils on endothelial cells causing damage and clot formation because of exposed collagen,21,22 stimulation of platelet activation and aggregation by major basic protein and eosinophil peroxidase,23 and the roles of CD40L expressed on blood eosinophils and CD40 expressed on endothelial cells during eosinophil activation.24 Recently, Wang et al25 reported that hypothiocyanate, an eosinophil peroxidase product, is a potent inducer of tissue factor activity in endothelial cells and postulated that this may promote thrombogenesis in HES.

No hypodense eosinophils, corresponding to the activated degranulated cells, were found in the skin or the circulation of our patients. In addition, in cases 1 and 2, there was no consistent association of SVT relapse with peripheral blood eosinophilia. Two explanations can be proposed. First, organ damage secondary to eosinophil infiltrate is not always associated with peripheral blood eosinophilia. Fuzellier et al26 recently reported eosinophilic endocarditis requiring mitral valve replacement related to HES with blood eosinophil counts within reference limits, suggesting a rapid homing of eosinophils into tissues. The STV relapses without eosinophilia in cases 1 and 2 could have been associated with superficial venous eosinophil infiltration that was not detected because the biopsies were not repeated. However, this hypothesis appears improbable because there was no infiltrate of eosinophils in the initial biopsy specimens from these patients. Second, SVT could be a consequence of the systemic release of prothrombotic substances (eg, hypothiocyanate) by tissue eosinophils (eg, gastric eosinophils in case 2).

In all of our cases, initiation of corticosteroid and anticoagulant therapy led to dramatic regression of the SVT and restoration of the eosinophil count to reference limits, but SVT relapse occurred on tapering of the corticosteroid dosage. Treatment of the relapses with interferon alfa resulted in resolution of the SVT and prolonged remission of the underlying HES in 2 patients. Interferon alfa is effective in HES27,28 by inhibiting eosinophil colony formation and interleukin 5 production by T cells29 and by decreasing the release of toxic eosinophilic substances.30 However, interferon alfa therapy can be complicated by Raynaud phenomenon and digital necrosis in HES31 and chronic myeloid leukemia,32 and direct toxic effects of interferon alfa on endothelial cells have been suggested by experimental data in mice.33 The rapid efficacy of interferon alfa for the treatment of SVT in our patients was likely the consequence of its direct effects on eosinophils. Recently, new treatments of HES targeted to pathogenic mechanisms have emerged, such as imatinib mesylate (especially in HES associated with the FIP1L1-PDGFRA fusion gene)9,34,35 and mepolizumab (monoclonal anti–interleukin 5 antibody).36,37 These treatments were not used in our patients because of the absence of gene fusion (for imatinib mesylate) and the inaccessibility of the medication (for mepolizumab).

Anticoagulant therapy is probably indicated in HES-related SVT, unlike idiopathic SVT, because of the increased thrombotic risk associated with HES. Considering the proposed pathogenic mechanisms for the thrombogenesis, both anticoagulant and antiplatelet drugs could be used. Anti–vitamin K anticoagulants would compensate for the lack of thrombomodulin (a key component of the protein C anticoagulant pathway38) and increased tissue factor activity,39 whereas antiplatelet agents would combat platelet activation due to endothelial damage, stimulation by eosinophil major basic protein, and tissue factor activity. However, our patients experienced relapse despite the use of these treatments.

We have reported, to our knowledge, the first 3 cases of SVT related to HES. Superficial venous thrombophlebitis in this setting represents a therapeutic challenge, and interferon alfa therapy can be helpful in preventing relapse and reducing dependence on corticosteroids. Further studies are needed to improve our knowledge of the mechanisms underlying thrombogenesis in HES.

Correspondence: Anne-Marie Piette, MD, Service de Médecine Interne, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France (am.piette@hopital-foch.org).

Financial Disclosure: None reported.

Accepted for Publication: June 1, 2006.

Author Contributions:Study concept and design: Terrier, Piette, Blétry, and Kahn. Acquisition of data: Terrier, Piette, Kerob, Cordoliani, Tancrède, Hamidou, Lebbé, Blétry, and Kahn. Analysis and interpretation of data: Terrier, Piette, Kerob, Cordoliani, Blétry, and Kahn. Drafting of the manuscript: Terrier and Kahn. Critical revision of the manuscript for important intellectual content: Terrier, Piette, Kerob, Cordoliani, Tancrède, Hamidou, Lebbé, Blétry, and Kahn. Study supervision: Terrier, Piette, Blétry, and Kahn.

Kikuchi  KMinami  KMiyakawa  HIshibashi  M Portal vein thrombosis in hypereosinophilic syndrome. Am J Gastroenterol 2002;971274- 1275
PubMed
Fitzpatrick  JEJohnson  CSimon  POwenby  J Cutaneous microthrombi: a histologic clue to the diagnosis of hypereosinophilic syndrome. Am J Dermatopathol 1987;9419- 422
PubMed
Kanno  HOuchi  NSato  MWada  TSawai  T Hypereosinophilia with systemic thrombophlebitis. Hum Pathol 2005;36585- 589
PubMed
Schulman  HHertzog  LZirkin  HHertzanu  Y Cerebral sinovenous thrombosis in the idiopathic hypereosinophilic syndrome in childhood. Pediatr Radiol 1999;29595- 597
PubMed
Vargas  CAMaldonado  OBotero  RC  et al.  Budd-Chiari syndrome associated with the hypereosinophilic syndrome [letter]. Am J Gastroenterol 1993;881802- 1803
PubMed
Kojima  KSasaki  T Veno-occlusive disease in hypereosinophilic syndrome. Intern Med 1995;341194- 1197
PubMed
Kocaturk  HYilmaz  M Idiopathic hypereosinophilic syndrome associated with multiple intracardiac thrombi. Echocardiography 2005;22675- 676
PubMed
Chusid  MJDale  DCWest  BCWolff  SM The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 1975;541- 27
PubMed
Cools  JDeAngelo  DJGotlib  J  et al.  A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003;3481201- 1214
PubMed
Roufosse  FCogan  EGoldman  M Recent advances in pathogenesis and management of hypereosinophilic syndromes. Allergy 2004;59673- 689
PubMed
Weller  PFBubley  GJ The idiopathic hypereosinophilic syndrome. Blood 1994;832759- 2779
PubMed
Gleich  GJSchroeter  ALMarcoux  JPSachs  MIO’Connell  EJKohler  PF Episodic angioedema associated with eosinophilia. N Engl J Med 1984;3101621- 1626
PubMed
Kazmierowski  JAChusid  MJParrillo  JEFauci  ASWolff  SM Dermatologic manifestations of the hypereosinophilic syndrome. Arch Dermatol 1978;114531- 535
PubMed
Aractingi  SBachmeyer  CPautier  P  et al.  Necrotic cutaneous lesions induced by hypereosinophilic syndrome secondary to a T-cell lymphoma. J Am Acad Dermatol 2002;46S133- S136
PubMed
Jang  KALim  YSChoi  JHSung  KJMoon  KCKoh  JK Hypereosinophilic syndrome presenting as cutaneous necrotizing eosinophilic vasculitis and Raynaud's phenomenon complicated by digital gangrene. Br J Dermatol 2000;143641- 644
PubMed
Oppliger  RGay-Crosier  FDayer  EHauser  C Digital necrosis in a patient with hypereosinophilic syndrome in the absence of cutaneous eosinophilic vasculitis. Br J Dermatol 2001;1441087- 1090
PubMed
Liao  YHSu  YWTsay  WChiu  HC Association of cutaneous necrotizing eosinophilic vasculitis and deep vein thrombosis in hypereosinophilic syndrome. Arch Dermatol 2005;1411051- 1053
PubMed
Narayan  SEzughah  FStanden  GRPawade  JKennedy  CT Idiopathic hypereosinophilic syndrome associated with cutaneous infarction and deep venous thrombosis. Br J Dermatol 2003;148817- 820
PubMed
Ferguson  GTStarkebaum  G Thromboangiitis obliterans associated with idiopathic hypereosinophilia. Arch Intern Med 1985;1451726- 1728
PubMed
Slungaard  AVercellotti  GMTran  TGleich  GJKey  NS Eosinophil cationic granule proteins impair thrombomodulin function: a potential mechanism for thromboembolism in hypereosinophilic heart disease. J Clin Invest 1993;911721- 1730
PubMed
Wassom  DLLoegering  DASolley  GO  et al.  Elevated serum levels of the eosinophil granule major basic protein in patients with eosinophilia. J Clin Invest 1981;67651- 661
PubMed
Slungaard  AVercellotti  GMWalker  GNelson  RDJacob  HS Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium. J Exp Med 1990;1712025- 2041
PubMed
Rohrbach  MSWheatley  CLSlifman  NRSlifman  NRGleich  GJ Activation of platelets by eosinophil granule proteins. J Exp Med 1990;1721271- 1274
PubMed
Gauchat  JFHenchoz  SFattah  D  et al.  CD40 ligand is functionally expressed on human eosinophils. Eur J Immunol 1995;25863- 865
PubMed
Wang  JGMahmud  SThompson  JAGeng  JGKey  NSSlungaard  A The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states. Blood 2005;107558- 565
PubMed
Fuzellier  JFChapoutot  LTorossian  PFMetz  DBaehrel  B Mitral valve replacement in idiopathic eosinophilic endocarditis without peripheral eosinophilia. J Card Surg 2005;20472- 474
PubMed
Coutant  GBletry  OPrin  L  et al.  Treatment of hypereosinophilic syndromes of myeloproliferative expression with the combination of hydroxyurea and interferon alpha: apropos of 7 cases [in French]. Ann Med Interne (Paris) 1993;144243- 250
PubMed
Butterfield  JHGleich  GJ Interferon-α treatment of six patients with the idiopathic hypereosinophilic syndrome. Ann Intern Med 1994;121648- 653
PubMed
Schandene  LDel Prete  GFCogan  E  et al.  Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+ T cells. J Clin Invest 1996;97309- 315
PubMed
Aldebert  DLamkhioued  BDesaint  C  et al.  Eosinophils express a functional receptor for interferon α: inhibitory role of interferon α on the release of mediators. Blood 1996;872354- 2360
PubMed
Liozon  EDelaire  LLacroix  P  et al.  Raynaud syndrome complicated by digital gangrene during treatment with interferon-α [in French]. Rev Med Interne 1997;18316- 319
PubMed
Bachmeyer  CFarge  DGluckman  EMiclea  JMAractingi  S Raynaud's phenomenon and digital necrosis induced by interferon-alpha. Br J Dermatol 1996;135481- 483
PubMed
Moss  JShore  IWoodrow  DGresser  I Interferon-induced glomerular basement membrane and endothelial cell lesions in mice: an immunogold ultrastructural study of basement membrane components. Am J Pathol 1988;133557- 563
PubMed
Gleich  GJLeiferman  KMPardanani  ATefferi  AButterfield  JH Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet 2002;3591577- 1578
PubMed
Pardanani  AReeder  TPorrata  LF  et al.  Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders. Blood 2003;1013391- 3397
PubMed
Plotz  SGSimon  HUDarsow  U  et al.  Use of an anti–interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. N Engl J Med 2003;3492334- 2339
PubMed
Garrett  JKJameson  SCThomson  B  et al.  Anti–interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol 2004;113115- 119
PubMed
Weiler  H Mouse models of thrombosis: thrombomodulin. Thromb Haemost 2004;92467- 477
PubMed
Toschi  VGallo  RLettino  M  et al.  Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation 1997;95594- 599
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

Superficial venous thrombophlebitis in the lower limb veins, seen as a reticulate array of erythematous and tender cords, in the patient in case 1. No livedo reticularis was noted on the physical examination.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Clinical and therapeutic time courses of the patients in the 3 cases. Arrows indicate relapses of superficial venous thrombophlebitis (SVT) or hypereosinophilic syndrome–related complications.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Laboratory Tests of the Patients in the 3 Cases*

References

Kikuchi  KMinami  KMiyakawa  HIshibashi  M Portal vein thrombosis in hypereosinophilic syndrome. Am J Gastroenterol 2002;971274- 1275
PubMed
Fitzpatrick  JEJohnson  CSimon  POwenby  J Cutaneous microthrombi: a histologic clue to the diagnosis of hypereosinophilic syndrome. Am J Dermatopathol 1987;9419- 422
PubMed
Kanno  HOuchi  NSato  MWada  TSawai  T Hypereosinophilia with systemic thrombophlebitis. Hum Pathol 2005;36585- 589
PubMed
Schulman  HHertzog  LZirkin  HHertzanu  Y Cerebral sinovenous thrombosis in the idiopathic hypereosinophilic syndrome in childhood. Pediatr Radiol 1999;29595- 597
PubMed
Vargas  CAMaldonado  OBotero  RC  et al.  Budd-Chiari syndrome associated with the hypereosinophilic syndrome [letter]. Am J Gastroenterol 1993;881802- 1803
PubMed
Kojima  KSasaki  T Veno-occlusive disease in hypereosinophilic syndrome. Intern Med 1995;341194- 1197
PubMed
Kocaturk  HYilmaz  M Idiopathic hypereosinophilic syndrome associated with multiple intracardiac thrombi. Echocardiography 2005;22675- 676
PubMed
Chusid  MJDale  DCWest  BCWolff  SM The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 1975;541- 27
PubMed
Cools  JDeAngelo  DJGotlib  J  et al.  A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003;3481201- 1214
PubMed
Roufosse  FCogan  EGoldman  M Recent advances in pathogenesis and management of hypereosinophilic syndromes. Allergy 2004;59673- 689
PubMed
Weller  PFBubley  GJ The idiopathic hypereosinophilic syndrome. Blood 1994;832759- 2779
PubMed
Gleich  GJSchroeter  ALMarcoux  JPSachs  MIO’Connell  EJKohler  PF Episodic angioedema associated with eosinophilia. N Engl J Med 1984;3101621- 1626
PubMed
Kazmierowski  JAChusid  MJParrillo  JEFauci  ASWolff  SM Dermatologic manifestations of the hypereosinophilic syndrome. Arch Dermatol 1978;114531- 535
PubMed
Aractingi  SBachmeyer  CPautier  P  et al.  Necrotic cutaneous lesions induced by hypereosinophilic syndrome secondary to a T-cell lymphoma. J Am Acad Dermatol 2002;46S133- S136
PubMed
Jang  KALim  YSChoi  JHSung  KJMoon  KCKoh  JK Hypereosinophilic syndrome presenting as cutaneous necrotizing eosinophilic vasculitis and Raynaud's phenomenon complicated by digital gangrene. Br J Dermatol 2000;143641- 644
PubMed
Oppliger  RGay-Crosier  FDayer  EHauser  C Digital necrosis in a patient with hypereosinophilic syndrome in the absence of cutaneous eosinophilic vasculitis. Br J Dermatol 2001;1441087- 1090
PubMed
Liao  YHSu  YWTsay  WChiu  HC Association of cutaneous necrotizing eosinophilic vasculitis and deep vein thrombosis in hypereosinophilic syndrome. Arch Dermatol 2005;1411051- 1053
PubMed
Narayan  SEzughah  FStanden  GRPawade  JKennedy  CT Idiopathic hypereosinophilic syndrome associated with cutaneous infarction and deep venous thrombosis. Br J Dermatol 2003;148817- 820
PubMed
Ferguson  GTStarkebaum  G Thromboangiitis obliterans associated with idiopathic hypereosinophilia. Arch Intern Med 1985;1451726- 1728
PubMed
Slungaard  AVercellotti  GMTran  TGleich  GJKey  NS Eosinophil cationic granule proteins impair thrombomodulin function: a potential mechanism for thromboembolism in hypereosinophilic heart disease. J Clin Invest 1993;911721- 1730
PubMed
Wassom  DLLoegering  DASolley  GO  et al.  Elevated serum levels of the eosinophil granule major basic protein in patients with eosinophilia. J Clin Invest 1981;67651- 661
PubMed
Slungaard  AVercellotti  GMWalker  GNelson  RDJacob  HS Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium. J Exp Med 1990;1712025- 2041
PubMed
Rohrbach  MSWheatley  CLSlifman  NRSlifman  NRGleich  GJ Activation of platelets by eosinophil granule proteins. J Exp Med 1990;1721271- 1274
PubMed
Gauchat  JFHenchoz  SFattah  D  et al.  CD40 ligand is functionally expressed on human eosinophils. Eur J Immunol 1995;25863- 865
PubMed
Wang  JGMahmud  SThompson  JAGeng  JGKey  NSSlungaard  A The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states. Blood 2005;107558- 565
PubMed
Fuzellier  JFChapoutot  LTorossian  PFMetz  DBaehrel  B Mitral valve replacement in idiopathic eosinophilic endocarditis without peripheral eosinophilia. J Card Surg 2005;20472- 474
PubMed
Coutant  GBletry  OPrin  L  et al.  Treatment of hypereosinophilic syndromes of myeloproliferative expression with the combination of hydroxyurea and interferon alpha: apropos of 7 cases [in French]. Ann Med Interne (Paris) 1993;144243- 250
PubMed
Butterfield  JHGleich  GJ Interferon-α treatment of six patients with the idiopathic hypereosinophilic syndrome. Ann Intern Med 1994;121648- 653
PubMed
Schandene  LDel Prete  GFCogan  E  et al.  Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+ T cells. J Clin Invest 1996;97309- 315
PubMed
Aldebert  DLamkhioued  BDesaint  C  et al.  Eosinophils express a functional receptor for interferon α: inhibitory role of interferon α on the release of mediators. Blood 1996;872354- 2360
PubMed
Liozon  EDelaire  LLacroix  P  et al.  Raynaud syndrome complicated by digital gangrene during treatment with interferon-α [in French]. Rev Med Interne 1997;18316- 319
PubMed
Bachmeyer  CFarge  DGluckman  EMiclea  JMAractingi  S Raynaud's phenomenon and digital necrosis induced by interferon-alpha. Br J Dermatol 1996;135481- 483
PubMed
Moss  JShore  IWoodrow  DGresser  I Interferon-induced glomerular basement membrane and endothelial cell lesions in mice: an immunogold ultrastructural study of basement membrane components. Am J Pathol 1988;133557- 563
PubMed
Gleich  GJLeiferman  KMPardanani  ATefferi  AButterfield  JH Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet 2002;3591577- 1578
PubMed
Pardanani  AReeder  TPorrata  LF  et al.  Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders. Blood 2003;1013391- 3397
PubMed
Plotz  SGSimon  HUDarsow  U  et al.  Use of an anti–interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. N Engl J Med 2003;3492334- 2339
PubMed
Garrett  JKJameson  SCThomson  B  et al.  Anti–interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol 2004;113115- 119
PubMed
Weiler  H Mouse models of thrombosis: thrombomodulin. Thromb Haemost 2004;92467- 477
PubMed
Toschi  VGallo  RLettino  M  et al.  Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation 1997;95594- 599
PubMed

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.