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Observation |

Keratosis Pilaris Rubra:  A Common but Underrecognized Condition FREE

Ann L. Marqueling, MD; Amy E. Gilliam, MD; Julie Prendiville, MD; Alex Zvulunov, MD; Richard J. Antaya, MD; Jeffrey Sugarman, MD, PhD; Mei-Lin Pang, MD; Phillip Lee, MD; Lawrence Eichenfield, MD; Brandie Metz, MD; Gerald N. Goldberg, MD; Roderic J. Phillips, MD; Ilona J. Frieden, MD
[+] Author Affiliations

Author Affiliations: Departments of Dermatology, University of California, San Francisco (Drs Marqueling, Gilliam, Sugarman, and Frieden), San Diego (Drs Pang, Lee, Eichenfield, and Metz), and Irvine (Dr Metz); University of British Columbia, Vancouver (Dr Prendiville), and Yale University, New Haven, Conn (Dr Antaya); Department of Pediatric Dermatology, Schneider Children's Medical Center, New Hyde Park, NY (Dr Zvulunov); Department of Pediatrics, Royal Children's Hospital, Parkville, Victoria, Australia (Dr Phillips); and Pima Dermatology, Tucson, Ariz (Dr Goldberg).


Arch Dermatol. 2006;142(12):1611-1616. doi:10.1001/archderm.142.12.1611.
Text Size: A A A
Published online

ABSTRACT

Background  Keratosis pilaris is a common skin disorder of childhood that often improves with age. Less common variants of keratosis pilaris include keratosis pilaris atrophicans and atrophodermia vermiculata.

Observations  In this case series from dermatology practices in the United States, Canada, Israel, and Australia, the clinical characteristics of 27 patients with keratosis pilaris rubra are described. Marked erythema with follicular prominence was noted in all patients, most commonly affecting the lateral aspects of the cheeks and the proximal arms and legs, with both more marked erythema and widespread extent of disease than in keratosis pilaris. The mean age at onset was 5 years (range, birth to 12 years). Sixty-three percent of patients were male. No patients had atrophy or scarring from their lesions. Various treatments were used, with minimal or no improvement in most cases.

Conclusions  Keratosis pilaris rubra is a variant of keratosis pilaris, with more prominent erythema and with more widespread areas of skin involvement in some cases, but without the atrophy or hyperpigmentation noted in certain keratosis pilaris variants. It seems to be a relatively common but uncommonly reported condition.

Figures in this Article

Keratosis pilaris (KP) is a common benign disorder of unknown etiology.1 It typically presents as an eruption of symmetric, asymptomatic, grouped keratotic follicular papules on the extensor and lateral aspects of the proximal extremities and the cheeks.15 Less often, KP may involve the neck, torso, and buttocks, and, rarely, the eruption may be generalized.5 Erythema, when present, is usually mild and localized to the perifollicular skin.4 Often, the disease is familial, and it has been suggested that inheritance is autosomal dominant1,2 without known predisposition based on race or sex. Keratosis pilaris develops most often in early childhood, with remission by adulthood in many patients.

At least 2 distinct variants of KP have been reported: keratosis pilaris atrophicans (KPA; sometimes referred to as ulerythema ophryogenes) and erythromelanosis follicularis faciei et colli (EFFC). We describe 27 patients with another variant of KP, which we have termed keratosis pilaris rubra (KPR), that, in our experience, is much more common than either KPA or EFFC. It is characterized by substantial erythema, widespread involvement, and persistence after the onset of puberty. Despite being relatively common, to our knowledge, a detailed case series has not been described in the medical literature to date.

REPORT OF CASES

CASE 1

A 13-year-old boy (patient 1 in the Table) presented to the University of California, San Francisco, pediatric dermatology practice with a 1-year history of a mildly pruritic but otherwise asymptomatic rash involving the face, torso, and extremities. The medical history was unremarkable. Before presentation, he had treated the eruption with hydrocortisone cream, which provided some relief of pruritus, and adapalene gel, which did not result in any improvement. Physical examination revealed bilateral erythematous patches with follicular prominence on the cheeks (Figure 1) and follicular hyperkeratotic papules with variable erythema on the chest, back, upper arms, and thighs. A punch biopsy specimen from the posterior aspect of the left shoulder showed follicular infundibular plugging with slight perifollicular inflammation and fibrosis, consistent with KP. The serum vitamin A level was normal (40 μg/dL [1.40 μmol/L]). Prescribed 0.05% tazarotene cream caused peeling and a sensation of burning, with minimal improvement.

Place holder to copy figure label and caption
Figure 1.

Case 1. Note the erythematous patches with follicular prominence on the cheeks.

Graphic Jump Location
Table Graphic Jump LocationTable. Clinical Characteristics of 27 Patients
CASE 2

A 4-year-old boy (patient 2 in the Table) presented to the University of California, San Francisco, pediatric dermatology practice with a 3-year history of facial erythema. The intensity of the erythema waxed and waned but never completely resolved. The child had mild pruritus in the areas of erythema, with no other symptoms. There was no response to treatment with over-the-counter moisturizing creams or lotions [Eucerin (Beiersdorf, Inc, Wilton, Conn], Cetaphil [Galderma Laboratories, Fort Worth, Tex], ammonium lactate moisturizer (Lac-Hydrin [Westwood-Squibb Pharmaceuticals, Inc, Princeton, NJ]), or 0.3% tacrolimus ointment. Medical history and family history were unremarkable. Physical examination revealed erythema and fine follicular papules on the forehead directly above the eyebrows and on both cheeks. The chin also exhibited erythema and follicular papules with a rough, sandpaper quality. There was questionable lateral eyebrow thinning bilaterally, but no follicular atrophy or scarring was noted. Both ears were erythematous but felt less rough than other affected areas. Typical areas of KP were present on the upper arms and upper lateral surfaces of the thighs (Figure 2).

Place holder to copy figure label and caption
Figure 2.

Case 2. Note the erythema and fine follicular papules on the cheeks (A) and the forehead directly above the eyebrows (B). There is questionable lateral eyebrow thinning but no follicular atrophy or scarring.

Graphic Jump Location

METHODS

Another 25 cases were collected during a 3-month period from physicians who received an e-mail via the Society for Pediatric Dermatology ListServe requesting data on cases similar to our index cases. Responses were received from the United States, Canada, Israel, and Australia. Physicians were sent a data collection sheet asking for information including patient age, sex, and race; age at onset of the disease; age when first seen by a dermatologist; symptoms; other skin conditions; other medical conditions; physical examination findings including location and description of the involved areas, extent of erythema, and other cutaneous findings; pathologic findings if a biopsy specimen was obtained; treatment; and response to treatment. Approval for the study was granted by the University of California, San Francisco, Committee on Human Research.

RESULTS

Of the 27 patients, 17 (63%) were boys and 10 (37%) were girls. The mean age at onset of disease was 5 years (range, birth to 12 years; SD, 4 years). Twenty patients (74%) were white. In most patients the eruption was asymptomatic, although a few patients noted occasional pruritus. Six patients (22%) reported a history of asthma, and 3 (11%) had a history of allergic rhinitis. Of 23 patients with sufficient descriptions of involved anatomic sites, 21 (91%) had substantial involvement of the face and body. Lesions on the face were typically erythematous keratotic papules with follicular accentuation, without evidence of scarring or hair loss, except in 1 patient (patient 11), who had hair loss of the eyebrows. Facial involvement included the cheeks in 17 patients (74%), the eyebrows in 6 (26%), the ears in 5 (22%), the chin in 4 (17%), the forehead in 3 (13%), and the glabella in 2 (9%). The specific facial location was not described in 4 patients (17%). Other sites of involvement included the lateral or extensor aspects of the arms in all patients, the torso in 13 (57%), the legs in 12 (52%), and the buttocks in 5 (22%). Most of the 27 patients in this case series had no other skin findings, but those noted included acne in 3 patients (11%), atopic dermatitis or an eczematous eruption in 3 (11%), various nevi in 2 (7%), and acanthosis nigricans, molluscum contagiosum, and warts in 1 each (4%). Except for atopic disease (asthma, atopic dermatitis, or allergic rhinitis) in 6 patients, no other consistent medical conditions were noted.

Treatments given for KPR in these patients included emollients; emollients containing urea, lactic acid, topical corticosteroids, or a combination of these ingredients; topical agents containing cholecalciferol, topical or systemic retinoid agents; topical corticosteroids; topical salicylic acid; and pulsed-dye laser therapy. In most patients, there was no substantial improvement with these treatments; 1 patient had a partial response to oral isotretinoin.

COMMENT

Keratosis pilaris is a common condition that has been seen in association with several disorders, including ichthyosis vulgaris and ichthyosis-like phenotype accompanying dry skin and atopy,6 cardiofaciocutaneous syndrome,7 metabolic disturbances (eg, malnutrition and hypovitaminosis A),3 Noonan syndrome, Down syndrome, diabetes mellitus, and obesity.8,9 Given its frequency, some of these associations could be coincidental. Treatments for KP commonly include emollients, keratolytic agents, topical corticosteroids, and topical retinoids, but these are often ineffective in diminishing the appearance of KP.4

Erythema is sometimes present in KP, but is usually mild and limited to the perifollicular skin.4 When perifollicular erythema is more noticeable, the disorder has been called KPR by some authors.1,4,5 The only study that examined KPR in detail was observational.10 Voss10 studied a large number of patients with KP, but he used the term keratosis follicularis, which is also used as a synonym for Darier disease. He differentiated 2 forms, keratosis follicularis alba and keratosis follicularis rubra. The alba form is described as manifesting with follicular papules without erythema, most commonly in children younger than 10 years, with both sexes affected equally, and decreasing in frequency with increasing age. The rubra form is described as having erythematous follicular-based papules. It was noted to increase in frequency with increasing age, was most common in patients 20 to 40 years of age, and was twice as common in women than in men. X-linked dominant inheritance of the rubra form was suggested. Although the clinical description of keratosis follicularis rubra by Voss parallels that in our patients with KPR, nearly two thirds of our patients were boys. In addition, our patients were younger when seen by a physician, with ages ranging from birth to 12 years. Since our cases were acquired primarily from pediatric dermatology practices, however, the lack of older patients may be an ascertainment bias. Voss10 also emphasized the commonness of this condition; in his series, the rubra variant occurred in 25% of the patient population studied.

Using multiple search strategies on both the PubMed and EMBASE databases (search terms included keratosis pilaris rubra, keratosis pilaris, keratosis pilaris atrophicans, keratosis pilaris faciei, and keratosis follicularis) and review of major dermatology textbooks, we found that the term keratosis pilaris rubra has appeared in a few publications,1,4,5 but there was only 1 detailed case description of KPR.11 This patient had rosy cheeks since infancy, with progressive erythema during childhood. At age 15 years, she had erythema and small papules on the cheeks and chin, without atrophy; sparse eyebrows; and erythema and KP on the extensor aspects of the arms and thighs. Potassium titanyl phosphate laser therapy resulted in improvement of symptoms.

Several other conditions with clinical features that overlap with KPR have been described. That which most closely approximates KPR is EFFC, which typically develops later in life, most often in the second decade, and is more common in male patients.12,13 The condition is also characterized by fine follicular papules with perifollicular erythema involving the cheeks, forehead, and neck. The eruption is usually symmetric. Concomitant KP on the arms has been noted in a few patients with EFFC.1416 Features that differentiate EFFC from KPR are lack of reported involvement on the torso and the presence of hyperpigmentation. Erythromelanosis follicularis faciei et colli and KPA, another KP variant, have been considered by some authors to be variants of the same condition,12 but EFFC lacks scarring. The similarities between KPR and EFFC, however, are striking, and photographs of EFFC in some reports show findings that are virtually identical to those in our cases,16 which suggests that they are likely part of the same disease spectrum. The hyperpigmentation noted in EFFC may, at least in part, be related to skin pigmentation type, with darker skin types showing more evidence of hyperpigmentation. Two of the 27 patients in our case series had some degree of hyperpigmentation on the cheeks but were included because of the additional finding of more widespread involvement, not solely involvement of the face and neck. This, too, suggests that KPR and EFFC may be forms of the same condition.

Two other conditions with considerable clinical overlap with KPR are KPA and its more severe variant, atrophodermia vermiculata.17 The erythematous component of KPR persists or even worsens at puberty, without progression to scarring, whereas KPA results in scarring.1,2,18 In addition, the more widespread areas of skin involvement in KPR are less common in KPA, in which involvement is often localized to the face. Keratosis pilaris atrophicans is likely inherited in an autosomal dominant fashion with incomplete penetrance.19,20 Keratosis follicularis spinulosa decalvans, a rare condition with an X-linked dominant inheritance, can also be considered in the differential diagnosis. It is morphologically similar to KPA but is more widespread, resulting in a scarring alopecia involving the eyebrows, eyelashes, and scalp.2,21

Keratosis pilaris has been reported as a feature of cardiofaciocutaneous syndrome. This condition is characterized by congenital heart defects, characteristic facial anomalies, and ectodermal abnormalities including sparse and woolly hair, hyperkeratotic skin lesions, and a generalized ichthyosis-like condition.22,23 Mutations in 2 genes, Kirsten rat sarcoma viral oncogene homolog (KRAS) and v-raf murine sarcoma viral oncogene homolog B1 (BRAF), have recently been identified in patients with cardiofaciocutaneous syndrome,23 but only mutations of BRAF have been associated with the hyperkeratosis noted in this condition. This genetic abnormality suggests at least 1 possible putative locus for KP and may provide clues for future genetic studies.

A lack of reliable response to treatment is shared by all of the KP variants. Most of our patients received several treatments, without significant improvement. With the exception of patients (including one of ours) who have responded to systemic retinoid agents24,25 and the previously reported patient whose symptoms improved with potassium titanyl phosphate laser therapy, these treatments had minimal to no efficacy. Patients, especially those with prominent facial involvement, are often quite disturbed by the appearance of KPR. Because no treatment is uniformly effective, the potential risks and benefits of various therapies must be considered and explained to patients.

As with other forms of KP, the pathogenesis of KPR is not well understood. The erythema present in KPR fluctuates, and in some patients it is present even in areas without significant keratotic papules. This raises the question of whether flushing via autonomic dysregulation may have a role in the clinical manifestations.

In summary, we describe 27 patients with KPR, a variant of KP that has not been previously emphasized in the medical literature. We believe that KPR, while not so common as KP, is much more common than other KP variants such as KPA. Keratosis pilaris rubra shares many features with EFFC and may be part of the same disease spectrum. Treatments to date have had limited efficacy.

ARTICLE INFORMATION

Correspondence: Ilona J. Frieden, MD, Department of Dermatology, University of California, San Francisco, 1701 Divisadero St, Third Floor, San Francisco, CA 94143-0316 (friedeni@derm.ucsf.edu).

Financial Disclosure: None reported.

Accepted for Publication: May 18, 2006.

Author Contributions:Study concept and design: Marqueling and Frieden. Acquisition of data: Marqueling, Gilliam, Prendiville, Zvulunov, Antaya, Sugarman, Pang, Lee, Eichenfield, Metz, Goldberg, Phillips, and Frieden. Analysis and interpretation of data: Marqueling, Antaya, Eichenfield, and Frieden. Drafting of the manuscript: Marqueling, Zvulunov, Phillips, and Frieden. Critical revision of the manuscript for important intellectual content: Gilliam, Prendiville, Zvulunov, Antaya, Sugarman, Lee, Eichenfield, Metz, and Phillips. Administrative, technical, and material support: Zvulunov, Lee, Eichenfield, Metz, and Frieden. Study supervision: Gilliam, Antaya, and Metz.

REFERENCES

Griffiths  WADLeigh  IMMarks  R Disorders of keratinization. Champion  RHBurton  JLEbling  FJGeds.Textbook of Dermatology. 25th ed. Oxford, England Blackwell Scientific Publications Ltd1992;1352- 1355
Fritsch  P Follicular syndromes with inflammation and atrophy. Freedberg  IMEisen  AZWolff  KAusten  KFGoldsmith  LAKatz  SIeds.Fitzpatrick's Dermatology in General Medicine. 6th ed. New York, NY McGraw-Hill Co2003;713- 718
Forman  L Keratosis pilaris. Br J Dermatol 1954;66279- 282
PubMed Link to Article
Lateef  ASchwartz  RAJanniger  CK Keratosis pilaris. Cutis 1999;63205- 207
PubMed
Poskitt  LWilkinson  J Natural history of keratosis pilaris. Br J Dermatol 1994;130711- 713
PubMed Link to Article
Mevorah  BMarazzi  AFrenck  E The prevalence of accentuated palmoplantar markings and keratosis pilaris in atopic dermatitis, autosomal dominant ichthyosis and control dermatological patients. Br J Dermatol 1985;112679- 685
PubMed Link to Article
Weiss  GConfino  YShermer  ATrau  H Cutaneous manifestations in the cardiofaciocutaneous syndrome, a variant of the classical Noonan syndrome: report of a case and review of the literature. J Eur Acad Dermatol Venereol 2004;18324- 327
PubMed Link to Article
Yosipovitch  GMevorah  BMashiach  JChan  YDavid  M High body mass index, dry scaly leg skin and atopic conditions are highly associated with keratosis pilaris. Dermatology 2000;20134- 36
PubMed Link to Article
Yosipovitch  GHodak  EVardi  P  et al.  The prevalence of cutaneous manifestations in IDDM and their association with diabetes risk factors and microvascular complications [published correction appears in Diabetes Care. 1998;21:1032]. Diabetes Care 1998;21506- 509
PubMed Link to Article
Voss  M Keratosis follicularis: new genetic aspects [in German]. Hautarzt 1991;42319- 321
PubMed
Dawn  GUrcelay  MPatel  MStrong  AMM Keratosis rubra pilaris responding to potassium titanyl phosphate laser. Br J Dermatol 2002;147822- 823
PubMed Link to Article
Watt  TLKaiser  JS Erythromelanosis follicularis faciei et colli: a case report. J Am Acad Dermatol 1981;5533- 534
PubMed Link to Article
Yanez  SVelasco  JAGonzalez  MP Familial erythromelanosis follicularis faciei et colli: an autosomal recessive mode of inheritance. Clin Exp Dermatol 1993;18283- 285
PubMed Link to Article
Stephan  FAyoub  NKlein-Tomb  LTomb  R Erythromelanosis follicularis faciei et colli. Ann Dermatol Venereol 2002;12963- 65
PubMed
Mishima  YRudner  E Erythromelanosis follicularis faciei et colli. Dermatologica 1966;132269- 287
PubMed Link to Article
Ermertcan  ATOzturkcan  SSahin  MTTurkdogan  PSacar  T Erythromelanosis follicularis faciei et colli associated with keratosis pilaris in two brothers. Pediatr Dermatol 2006;2331- 34
PubMed Link to Article
Baden  HPByers  HR Clinical findings, cutaneous pathology, and response to therapy in 21 patients with keratosis pilaris atrophicans. Arch Dermatol 1994;130469- 475
PubMed Link to Article
Davenport  DD Ulerythema ophryogenes: review and report of a case. Arch Dermatol 1964;8974- 80
PubMed Link to Article
Callaway  SRLesher  JL Keratosis pilaris atrophicans: case series and review. Pediatr Dermatol 2004;2114- 17
PubMed Link to Article
Burnett  JWSchwartz  MFBerberian  BJ Ulerythema ophryogenes with multiple congenital anomalies. J Am Acad Dermatol 1988;18437- 440
PubMed Link to Article
Alfadley  AAl Hawsawi  KHainau  BAl Aboud  K Two brothers with keratosis follicularis spinulosa decalvans. J Am Acad Dermatol 2002;47S275- S278
PubMed Link to Article
Reynolds  JFNeri  GHerrmann  JP  et al.  New multiple congenital anomalies/mental retardation syndrome with cardio-facio-cutaneous involvement—the CFC syndrome. Am J Med Genet 1986;25413- 427
PubMed Link to Article
Niihori  TAoki  YNarumi  Y  et al.  Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Nat Genet 2006;38294- 296
PubMed Link to Article
Richard  GHarth  W Keratosis follicularis spinulosa decalvans: therapy with isotretinoin and etretinate in the inflammatory stage [in German]. Hautarzt 1993;44529- 534
PubMed
Layton  AMCunliffe  WJ A case report of ulerythema ophryogenes responding to isotretinoin. Br J Dermatol 1993;129645- 646
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

Case 1. Note the erythematous patches with follicular prominence on the cheeks.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Case 2. Note the erythema and fine follicular papules on the cheeks (A) and the forehead directly above the eyebrows (B). There is questionable lateral eyebrow thinning but no follicular atrophy or scarring.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Clinical Characteristics of 27 Patients

References

Griffiths  WADLeigh  IMMarks  R Disorders of keratinization. Champion  RHBurton  JLEbling  FJGeds.Textbook of Dermatology. 25th ed. Oxford, England Blackwell Scientific Publications Ltd1992;1352- 1355
Fritsch  P Follicular syndromes with inflammation and atrophy. Freedberg  IMEisen  AZWolff  KAusten  KFGoldsmith  LAKatz  SIeds.Fitzpatrick's Dermatology in General Medicine. 6th ed. New York, NY McGraw-Hill Co2003;713- 718
Forman  L Keratosis pilaris. Br J Dermatol 1954;66279- 282
PubMed Link to Article
Lateef  ASchwartz  RAJanniger  CK Keratosis pilaris. Cutis 1999;63205- 207
PubMed
Poskitt  LWilkinson  J Natural history of keratosis pilaris. Br J Dermatol 1994;130711- 713
PubMed Link to Article
Mevorah  BMarazzi  AFrenck  E The prevalence of accentuated palmoplantar markings and keratosis pilaris in atopic dermatitis, autosomal dominant ichthyosis and control dermatological patients. Br J Dermatol 1985;112679- 685
PubMed Link to Article
Weiss  GConfino  YShermer  ATrau  H Cutaneous manifestations in the cardiofaciocutaneous syndrome, a variant of the classical Noonan syndrome: report of a case and review of the literature. J Eur Acad Dermatol Venereol 2004;18324- 327
PubMed Link to Article
Yosipovitch  GMevorah  BMashiach  JChan  YDavid  M High body mass index, dry scaly leg skin and atopic conditions are highly associated with keratosis pilaris. Dermatology 2000;20134- 36
PubMed Link to Article
Yosipovitch  GHodak  EVardi  P  et al.  The prevalence of cutaneous manifestations in IDDM and their association with diabetes risk factors and microvascular complications [published correction appears in Diabetes Care. 1998;21:1032]. Diabetes Care 1998;21506- 509
PubMed Link to Article
Voss  M Keratosis follicularis: new genetic aspects [in German]. Hautarzt 1991;42319- 321
PubMed
Dawn  GUrcelay  MPatel  MStrong  AMM Keratosis rubra pilaris responding to potassium titanyl phosphate laser. Br J Dermatol 2002;147822- 823
PubMed Link to Article
Watt  TLKaiser  JS Erythromelanosis follicularis faciei et colli: a case report. J Am Acad Dermatol 1981;5533- 534
PubMed Link to Article
Yanez  SVelasco  JAGonzalez  MP Familial erythromelanosis follicularis faciei et colli: an autosomal recessive mode of inheritance. Clin Exp Dermatol 1993;18283- 285
PubMed Link to Article
Stephan  FAyoub  NKlein-Tomb  LTomb  R Erythromelanosis follicularis faciei et colli. Ann Dermatol Venereol 2002;12963- 65
PubMed
Mishima  YRudner  E Erythromelanosis follicularis faciei et colli. Dermatologica 1966;132269- 287
PubMed Link to Article
Ermertcan  ATOzturkcan  SSahin  MTTurkdogan  PSacar  T Erythromelanosis follicularis faciei et colli associated with keratosis pilaris in two brothers. Pediatr Dermatol 2006;2331- 34
PubMed Link to Article
Baden  HPByers  HR Clinical findings, cutaneous pathology, and response to therapy in 21 patients with keratosis pilaris atrophicans. Arch Dermatol 1994;130469- 475
PubMed Link to Article
Davenport  DD Ulerythema ophryogenes: review and report of a case. Arch Dermatol 1964;8974- 80
PubMed Link to Article
Callaway  SRLesher  JL Keratosis pilaris atrophicans: case series and review. Pediatr Dermatol 2004;2114- 17
PubMed Link to Article
Burnett  JWSchwartz  MFBerberian  BJ Ulerythema ophryogenes with multiple congenital anomalies. J Am Acad Dermatol 1988;18437- 440
PubMed Link to Article
Alfadley  AAl Hawsawi  KHainau  BAl Aboud  K Two brothers with keratosis follicularis spinulosa decalvans. J Am Acad Dermatol 2002;47S275- S278
PubMed Link to Article
Reynolds  JFNeri  GHerrmann  JP  et al.  New multiple congenital anomalies/mental retardation syndrome with cardio-facio-cutaneous involvement—the CFC syndrome. Am J Med Genet 1986;25413- 427
PubMed Link to Article
Niihori  TAoki  YNarumi  Y  et al.  Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Nat Genet 2006;38294- 296
PubMed Link to Article
Richard  GHarth  W Keratosis follicularis spinulosa decalvans: therapy with isotretinoin and etretinate in the inflammatory stage [in German]. Hautarzt 1993;44529- 534
PubMed
Layton  AMCunliffe  WJ A case report of ulerythema ophryogenes responding to isotretinoin. Br J Dermatol 1993;129645- 646
PubMed Link to Article

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