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Dactinomycin-Induced Cutaneous Toxic Effects During Treatment of Choriocarcinoma

Jeanette M. Waller, BA; Janet L. Maldonado, MD; Kieron S. Leslie, MRCP; Toby A. Maurer, MD
Arch Dermatol. 2006;142(12):1650-1666. doi:10.1001/archderm.142.12.1660.
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D’Angio  GJFarber  SMaddock  CL Potentiation of x-ray effects by actinomycin D. Radiology 1959;73175- 177
Kanwar  VSGahhar  ARibeiro  RCBowman  LParham  DMJenkins  JJ  III Unusual cutaneous toxicity following treatment with dactinomycin: a report of two cases. Med Pediatr Oncol 1995;24329- 333
PubMed Link to Article[[XSLOpenURL/10.1002/(ISSN)1096-911X]]
Coppes  MJJorgenson  KArlette  JP Cutaneous toxicity following the administration of dactinomycin. Med Pediatr Oncol 1997;29226- 227
PubMed Link to Article[[XSLOpenURL/10.1002/(ISSN)1096-911X]]
Van Gool  SWvan den Oord  JUyttebroeck  ABrock  P Cutaneous toxicity following administration of dactinomycin [letter]. Med Pediatr Oncol 1998;31128
PubMed Link to Article[[XSLOpenURL/10.1002/(ISSN)1096-911X]]
Rongioletti  FRebora  A Eccrine squamous syringometaplasia in chemotherapy-induced acral erythema. J Am Acad Dermatol 1992;26284
PubMed Link to Article[[XSLOpenURL/10.1016/S0190-9622(08)80334-9]]
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Figure 1.

Symmetrical eruptions affected the axilla with extensive dark brown confluent plaques with central desquamation and peripheral scaling.

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Figure 2.

Neck revealed multiple 3- to 5-mm, well-demarcated brown macules with a rim of darker brown hyperpigmentation.

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