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Correspondence |

Leukocytoclastic Vasculitis Masquerading as Hand-Foot Syndrome in a Patient Treated With Sorafenib

Nancy M. Chung, MD; Martin Gutierrez, MD; Maria L. Turner, MD
Arch Dermatol. 2006;142(11):1508-1518. doi:10.1001/archderm.142.11.1510.
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Hirte  HWMoore  MSiu  L  et al.  Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann Oncol 2005;161688- 1694
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Awada  AHendlisz  AGil  T  et al.  Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer 2005;921855- 1861
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Staehler  MRohrmann  KHaseke  NStief  CGSiebels  M Targeted agents for the treatment of advanced renal cell carcinoma. Curr Drug Targets 2005;6835- 846
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Strumberg  DAwada  AHirte  H  et al.  Pooled safety analysis of BAY 43-9006 (sorafenib) monotherapy in patients with advanced solid tumours: is rash associated with treatment outcome? Eur J Cancer 2006;42548- 556
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Robert  CSoria  JCSpatz  A  et al.  Cutaneous side-effects of kinase inhibitors and blocking antibodies. Lancet Oncol 2005;6491- 500
PubMed
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Figure 1.

Targetoid and round bullous lesions, some of which are hemorrhagic, are evident on the patient's hand, including in periungual and subungual areas.

Grahic Jump Location
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Figure 2.

Hematoxylin-eosin–stained skin biopsy specimens from our patient. A, Low-power view (original magnification ×4) showing an intraepidermal bulla with epidermal necrosis, papillary dermal hemorrhage, and vascular and perivascular infiltrate around superficial vessels. B, Higher-power view (original magnification ×20) of superficial capillaries with necrotic vessel walls infiltrated with polymorphonuclear leukocytes.

Grahic Jump Location

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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