We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
skINsight |

Dermoscopic Color Perspective

Kaare Weismann, MD, PhD; Henrik F. Lorentzen, MD
Arch Dermatol. 2006;142(9):1250. doi:10.1001/archderm.142.9.1250.
Text Size: A A A
Published online


Color variation of melanin depends on its location in the skin. In the stratum corneum and upper epidermis, melanin is jet black (appearing dermoscopically as dark spots); in the basal layer and dermoepidermal junction, it is brown (brown globules); in the papillary dermis it is blue-gray; and in the reticular dermis it is steel blue (blue nevus). Due to the Tyndall effect, in which short-wavelength visible light (blue) is dispersed and reflected more than long-wavelength light (red), the blue color of otherwise black melanin is explained by the depth of the pigment deep in the dermis. The dermoscopic image of a blue nevus in Figure 1A shows color perspective with change in color to blue and fading color intensity (pale blue) due to the Tyndall effect. The histopathologic image in Figure1B shows melanocytes deep in the dermis.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 6

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
High-resolution color-Doppler ultrasound for the study of skin growths. Arch Dermatol Res Published online Jan 21, 2015.;
Dermoscopic and clinical features of trunk melanomas. Postepy Dermatol Alergol 2014;31(6):362-7.

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Quick Reference

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Quick Reference