Eosinophils were first described in 1879 by Paul Ehrlich, who recognized their ability to stain with acid dyes, particularly eosin. The distinctive tinctorial properties of eosinophil granules give these cells a prominence in stained sections that contrasts with their lack of diagnostic power and still undefined role in pathogenesis. Eosinophils may be seen in skin biopsy specimens from patients with various inflammatory and neoplastic disorders, but they are among the diagnostic criteria in a limited number of diseases, including Wells syndrome, angiolymphoid hyperplasia with eosinophilia, and eosinophilic pustulosis.1,2
Eosinophil granule major basic protein immunostaining in urticaria: evidence for extensive granule protein deposition with few intact cells in an edematous reaction. A, Major basic protein staining in a urticarial lesion shows few intact perivascular cells (brightly staining ovals) and extensive extracellular major basic protein staining throughout the dermis, noted as distinct granules and confluent areas of deposition on connective tissue (original magnification ×160). B, Hematoxylin-eosin counterstaining of tissue section in A shows 1:1 correlation of intact cells, but the extensive extracellular major basic protein deposition is not visible (original magnification ×160).
Thank you for submitting a comment on this article. It will be reviewed by JAMA Dermatology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 8
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.