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Observation |

Congenital Plaque-Type Glomuvenous Malformations Presenting in Childhood FREE

Susan Bayliss Mallory, MD; Odile Enjolras, MD; Laurence M. Boon, MD, PhD; Erica Rogers, MD; David R. Berk, MD; Francine Blei, MD; Eulalia Baselga, MD; Anne-Marie Ros, MD; Miikka Vikkula, MD, PhD
[+] Author Affiliations

Author Affiliations: Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Mo (Drs Mallory, Rogers, and Berk); Consultation Multidisciplinaire des Angiomes, Hôpital Lariboisière, Paris, France (Dr Enjolras); Division of Plastic Surgery, Center for Vascular Anomalies, Cliniques Universitaires Saint-Luc (Dr Boon), and Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology, University of Louvain Medical School (Drs Boon and Vikkula), Brussels, Belgium; Department of Pediatrics, Stephen D. Hassenfeld Center of New York University Medical Center, New York (Dr Blei); Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (Dr Baselga); and Unit of Dermatology and Venereology, Department of Medicine, Karolinska Hospital, Stockholm, Sweden (Dr Ros).


Arch Dermatol. 2006;142(7):892-896. doi:10.1001/archderm.142.7.892.
Text Size: A A A
Published online

ABSTRACT

Background  Glomuvenous malformations (GVMs) are now considered a separate entity from venous malformations. The rarest type of GVM is the generalized congenital plaque-type GVM.

Observations  We present 10 new cases of congenital plaque-type GVM and describe their clinical progression and treatment. Mutations in the glomulin gene were found in those patients who participated in the genetic study.

Conclusions  Congenital plaque-type GVMs are unique in their congenital nature, extensive distribution, difficult to diagnose and treat, and progressive involvement after birth. Most cases are familial, yet affected relatives usually have only minor lesions. The lesions of congenital plaque-type GVM are severe, visible at birth, and usually mistaken for extensive venous malformations. Vascular malformations are divided by hemodynamic type into slow-flow and fast-flow lesions. Slow-flow lesions are subcategorized as capillary, lymphatic, and venous.1 Capillary malformations are flat, sharply demarcated, red-pink vascular stains of the skin commonly referred to as port-wine stains. These persist throughout life and are characterized histologically by dilated capillaries within the dermis. They slowly increase in size with age. Lymphatic malformations are spongelike collections of abnormal channels and spaces that contain clear lymphatic fluid, causing an excess of fluid to accumulate and dilate the lymphatic channels. This results in swelling of the affected area and, if extensive, can cause enlargement of soft tissues and bones.

Figures in this Article

Venous anomalies are composed of malformed channels lined by media that are focally deficient in smooth muscle cells. Some venous malformations (VMs) have an increased number of rounded cells in their walls known as glomus cells. In the past, these have been known as glomus tumors or glomangiomas. However, these lesions have now been renamed glomuvenous malformations (GVMs) to stress the fact that they are not true tumors as suggested by the suffix -oma2 but are indeed malformations presenting in the fetus. These lesions have been associated with a mutation in the glomulin gene.

We herein describe 10 patients with the rare generalized congenital plaque-type GVM. These lesions are unique in their congenital nature, extensive distribution, difficult to diagnose in a young patient, and progressive involvement after birth.1

REPORT OF CASES

Patients were accrued in the following way: 6 from France (examined by O.E.), including patients originally from Central Africa, Portugal, Iran, Algeria, and France; 2 from the United States (examined by S.B.M. and F.B.); 1 from Sweden (examined by A.-M.R.); and 1 from Spain (examined by E.B.).

CASE 1

An adopted white male infant from the United States with a normal prenatal history presented at 1 month of age with a vascular anomaly over his right leg (Figure 1) and a patchy macular vascular stain on his left arm. Both lesions were present from birth. By 6 months of age, he demonstrated a purple-pink vascular patch on his left leg, scrotum, and bilateral plantar feet. By 21 months of age, small vascular plaques were noted on his lower lip and face. At 17 months of age, magnetic resonance imaging of the brain, abdomen, and lower limbs was performed to evaluate the extent of the VM. Findings in the brain and abdomen were normal, with no evidence of abnormally dilated vascular structures. Findings in his lower extremity demonstrated numerous varicosities in the subcutaneous tissue of the right anteromedial thigh and leg. The venous system of both lower extremities was patent. Results of biopsies of shoulder and thigh lesions performed at 19 months of age showed GVM. Molecular studies were not performed. With time, it has become apparent that he has a mild form of autism but is otherwise healthy. At 2½ years of age, the lesions had become more apparent and nodular (Figure 2).

Place holder to copy figure label and caption
Figure 1.

A male infant at 1 month of age (case 1) with a red-purple plaque on the inner thigh and atrophy of the overlying cutis.

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Place holder to copy figure label and caption
Figure 2.

The patient in Figure 1 (case 1) at 2½ years of age. Lesions on the inner thigh have become more pronounced and nodular and do not change with compression of the area.

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CASE 5

A girl from Portugal was first examined in France at 9 years of age. She had a medical history of a ventricular septal defect. A large bluish purple plaque on her right trunk included her posterior shoulder and midline abdomen. She had a large, poorly compressible plaque on the posterior and anterior aspects of her right thigh that was composed of purple and blue nodules (Figure 3). She also had scattered blue nodules on the left thigh. Her lesions had been present at birth as flat, bluish or pink patches. With age, all the lesions slowly extended and thickened, particularly those on the thigh. A magnetic resonance image of the thigh showed only cutaneous and subcutaneous involvement. Results of a biopsy revealed GVM. She had no family history of similar lesions. No molecular studies were performed. She had no surgical treatment because she developed a keloid after her first biopsy.

Place holder to copy figure label and caption
Figure 3.

A girl at 9 years of age (case 5) with thickened purple nodules on the thigh.

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CASE 10

A newborn boy from Spain was seen shortly after birth with erythematous plaques that had been present since birth (Figure 4). He was born by spontaneous vaginal delivery at 34 weeks' gestation from a twin pregnancy after in vitro fertilization. His twin sister did not have any skin lesions.

Place holder to copy figure label and caption
Figure 4.

A male infant (case 10). A, As a neonate, he had pink patches with a surrounding dusky halo on his back. B, At 6 months of age, follow-up showed progression of the lesions with purple prominent vessels.

Graphic Jump Location

On physical examination, there were 4 erythematous, bluish, poorly demarcated patches on his back (Figure 4A). The patches were slightly depressed and warm to palpation, and the overlying skin was thickened. There was no thrill or bruit. No family history of similar lesions was obtained.

Results of a complete blood cell count, measurement of liver enzyme levels, renal function tests, and coagulation studies were normal. Ultrasonographic findings of the spine and abdomen were normal. A biopsy specimen revealed an increased number of ectatic vessels in the dermis, which were lined by 2 layers of cells and were interpreted as a capillary malformation.

On follow-up at 6 months of age, no new lesions had appeared, but lesions had become more prominent and annular (Figure 4B). The centers of the plaques were bluish and depressed, with prominent ectatic vessels. The periphery of each plaque was erythematous and petechial. The lesions were more prominent during crying and the Valsalva maneuver.

A second biopsy was performed, and results revealed numerous dilated vascular lumina in the dermis, which were lined by a single layer of flat endothelial cells and several rows of cuboidal cells with a pale nucleus and eosinophilic cytoplasm. Immunohistochemical staining demonstrated a positive reaction for α-smooth muscle actin, characteristic of glomus cells. Genetic testing was not performed.

COMMENT

At one time, GVMs were considered to be a subtype of VM, but are now known to be a separate entity because of their separate origin (Table 1). Molecular studies have permitted us to differentiate between inheritable cutaneomucosal VM (the inherited form of VM) and GVM, as they map to 2 different chromosomes with different genes.35 Familial VM (cutaneomucosal VM, 1%-2%3) is linked to a mutation of the protein receptor tyrosine kinase, epithelial-specific (TIE-2) gene, mapped to 9p21-22,6 whereas familial GVM (>64%3) is linked to a mutation of the glomulin gene, mapped to chromosome 1p21.2,4,7 Glomuvenous malformations occur as sporadic and inherited lesions. A large series of 135 patients with GVM showed no sex prevalence. A minimum of 64% of these cases were familial.3 The pattern of inheritance for multiple GVMs is autosomal dominant with incomplete penetrance and variable expressivity2,8,9 and involves mutations in the glomulin gene. The identification of a double-hit mutation in 1 patient with GVM suggests paradominant inheritance due to a complete loss of function of the glomulin gene.2 According to Happle and Konig,10 the large plaque-type GVM, superimposed on the ordinary phenotype of this autosomal dominant disorder, could be classified as a type 2 segmental manifestation caused by loss of heterozygosity in the embryo. Brouillard et al11 found that 70% of GVM families demonstrate 1 of the 4 common glomulin gene mutations.

Histologically, GVMs are nonencapsulated tumors with large, irregular cavities similar to VMs (cavernous hemangiomas), but the vascular spaces are lined by 1 or 2 layers of glomus cells. Glomus cells are rounded or polygonal cells with centrally placed round or ovoid nuclei and have scant eosinophilic cytoplasm.12 Multiple GVMs are less well circumscribed and less solid-appearing than solitary GVMs. They have more narrow and focal aggregates of glomus cells and larger vascular spaces than solitary GVMs.13 Immunohistochemical analysis demonstrates that GVM are positive for vimentin and α-smooth muscle actin but negative for desmin.1416 By in situ hybridization, glomulin has been shown to be expressed in murine embryonic and adult vascular smooth muscle cells.17 These findings support the proposed mesenchymal origin of GVM and provide evidence for abnormal vascular smooth muscle differentation.17,18

We can divide GVMs into solitary and multiple types. The most common type is a solitary nodule that may be painful. Multiple GVMs are rare and account for less than 10% of all reported cases.12,19 They have an earlier age of onset than solitary lesions, with one third presenting before 20 years of age. Multiple lesions can be subdivided into localized, disseminated, and congenital plaque-type forms.

The rare congenital plaque-type GVM was first described by Landthaler et al18 in 1990. They reported 2 cases of congenital multiple plaque-type GVM and proposed that the classification of multiple GVMs include this variant in addition to the disseminated and localized variants. In both cases reported by Landthaler et al,18 the lesions were noted within the first month of life and presented as plaques on the back. Histological features were identical to those reported in localized and disseminated types. In 1995, Glick et al20 reviewed the published reports of congenital plaque-type GVM in the world literature. Finally, Carvalho et al21 presented the first Brazilian case in 2001 and further reviewed the world literature.

We have been able to draw several conclusions from our case reports (Table 2). First, this specific congenital plaque-type form of GVM is severe, extensive, and visible at birth. However, like other forms of GVM, congenital plaque-type GVM is limited to the skin and subcutaneous tissue. Some cases are familial, whereas others appear to be sporadic.

Table Graphic Jump LocationTable 2. Characteristics of 10 Cases of Congenital Plaque-Type GVM

Second, in the familial cases, family members usually have minor lesions, often consisting of only 1 small nodule. Genetic counseling should include review of relatives for undiagnosed lesions and discussion of the nature of the disorder's autosomal dominant inheritance with incomplete penetrance and variable expressivity.

Third, congenital plaque-type GVM is often subtle, flat, and pink, bluish, or both at birth. These lesions are often misdiagnosed as capillary malformations, early VM, early hemangiomas, or even blue nevi. Some are particularly difficult to diagnose because they look partly atrophic at birth (eg, cases 1, 4, and 8). Any location (face, trunk, and extremities) may be affected.

Fourth, the typical clinical course of these lesions is progressive thickening (Figure 5), with new development of papules and nodules. The lesions tend to extend to adjacent areas not obviously involved at birth. If lesions are unilateral at birth, scattered nodules often develop on the contralateral side (plaque-type lesions are usually predominant on 1 side of the body) or in distant areas. Large lesions are poorly compressible.

Place holder to copy figure label and caption
Figure 5.

Case 3 at 2 years of age with a blue, thickened plaque on the face.

Graphic Jump Location

Fifth, lesions progress from pink or light blue plaques in infancy to deep, dark blue plaques in late childhood and adolescence. They also become painful when exacerbated by pressure during childhood. This symptom is well documented in the follow-up of our patients.

Sixth, histologically and genetically, there is no difference between this type of GVM and the more common type of GVM; however, some of our patients seem to have more rows of glomus cells in their vessel walls.

Seventh, treatment is difficult. Surgical excision should probably begin in infancy when lesions are not infiltrated, but this needs to be verified with future cases. Sclerotherapy and embolization in older patients, when GVM lesions are already thickened, did not help in some of our experiences. One patient (case 9) responded to flash-lamp pulsed-dye laser treatment.

In conclusion, we present 10 cases of congenital plaque-type GVM and verify that they are caused by a mutation in the glomulin gene in the 3 cases in which genetic studies were performed.

ARTICLE INFORMATION

Correspondence: Susan Bayliss Mallory, MD, Division of Dermatology, Department of Internal Medicine, St Louis Children's Hospital, One Children's Place, 3N 48, St Louis, MO 63110 (smallory@im.wustl.edu).

Financial Disclosure: None reported.

Previous Presentation: This study was presented in part at the American Dermatologic Association meeting; October 21, 2004; Napa Valley, Calif.

Accepted for Publication: January 10, 2006.

Author Contributions:Study concept and design: Mallory, Enjolras, Boon, and Vikkula. Acquisition of data: Mallory, Enjolras, Boon, Blei, Baselga, Ros, and Vikkula. Analysis and interpretation of data: Mallory, Enjolras, Boon, Rogers, Berk, Ros, and Vikkula. Drafting of the manuscript: Mallory, Boon, Rogers, Blei, Ros, and Vikkula. Critical revision of the manuscript for important intellectual content: Mallory, Enjolras, Boon, Berk, Baselga, Ros, and Vikkula. Obtained funding: Vikkula. Administrative, technical, and material support: Mallory, Boon, and Berk. Study supervision: Mallory, Enjolras, Boon, and Vikkula.

Funding/Support: These studies were partially supported by the Interuniversity Attraction Poles initiated by the Belgian Federal Science Policy, network 5/25; Concerted Research Actions Convention 02/07/276 of the Belgian French Community Ministry; the National Institute of Health Program Project P01 AR048564-01A1; and the Fonds National de la Recherche Scientifique (Dr Vikkula).

REFERENCES

Enjolras  OMulliken  JB Vascular tumors and vascular malformations (new issues). Adv Dermatol 1997;13375- 423
PubMed
Brouillard  PBoon  LMMulliken  JB  et al.  Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations (“glomangiomas”). Am J Hum Genet 2002;70866- 874
PubMed Link to Article
Boon  LMMulliken  JBEnjolras  OVikkula  M Glomuvenous malformation (glomangioma) and venous malformation: distinct clinicopathologic and genetic entities. Arch Dermatol 2004;140971- 976
PubMed Link to Article
Boon  LMBrouillard  PIrrthum  A  et al.  A gene for inherited cutaneous venous anomalies (“glomangiomas”) localizes to chromosome 1p21-22. Am J Hum Genet 1999;65125- 133
PubMed Link to Article
Boon  LMMulliken  JBVikkula  M  et al.  Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. Hum Mol Genet 1994;31583- 1587
PubMed Link to Article
Vikkula  MBoon  LMCarraway  KL  III  et al.  Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 1996;871181- 1190
PubMed Link to Article
Irrthum  ABrouillard  PEnjolras  O  et al.  Linkage disequilibrium narrows locus for venous malformation with glomus cells (VMGLOM) to a single 1.48 Mbp YAC. Eur J Hum Genet 2001;934- 38
PubMed Link to Article
Rudolph  R Familial multiple glomangiomas. Ann Plast Surg 1993;30183- 185
PubMed Link to Article
Tran  LPVelanovich  VKaufmann  CR Familial multiple glomus tumors: report of a pedigree and literature review. Ann Plast Surg 1994;3289- 91
PubMed Link to Article
Happle  RKonig  A Type 2 segmental manifestation of multiple glomus tumors: a review and reclassification of 5 case reports. Dermatology 1999;198270- 272
PubMed Link to Article
Brouillard  PGhassibe  MPenington  A  et al.  Four common glomulin mutations cause two thirds of glomuvenous malformations (“familial glomangiomas”): evidence for a founder effect. J Med Genet 2005;42e13
PubMed Link to Article
Taaffe  ABarker  DWyatt  EHBury  HP Glomus tumours: a clinico-pathological survey. Clin Exp Dermatol 1980;5219- 225
PubMed Link to Article
Farmer  ERedHood  AFed Pathology of the Skin.  East Norwalk, Conn Appleton & Lange1994;827- 834
Tarnowski  WMHashimoto  K Multiple glomus tumors: an ultrastructural study. J Invest Dermatol 1969;52474- 478
PubMed
Dervan  PATobbia  INCasey  MO’Loughlin  JO’Brien  M Glomus tumours: an immunohistochemical profile of 11 cases. Histopathology 1989;14483- 491
PubMed Link to Article
Kaye  VMDehner  LP Cutaneous glomus tumor: a comparative immunohistochemical study with pseudoangiomatous intradermal melanocytic nevi. Am J Dermatopathol 1991;132- 6
PubMed Link to Article
McIntyre  BABrouillard  PAerts  VGutierrez-Roelens  IVikkula  M Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse. Gene Expr Patterns 2004;4351- 358
PubMed Link to Article
Landthaler  MBraun-Falco  OEckert  FStolz  WDorn  MWolff  HH Congenital multiple plaquelike glomus tumors. Arch Dermatol 1990;1261203- 1207
PubMed Link to Article
Goodman  TFAbele  DC Multiple glomus tumors: a clinical and electron microscopic study. Arch Dermatol 1971;10311- 23
PubMed Link to Article
Glick  SAMarkstein  EAHerreid  P Congenital glomangioma: case report and review of the world literature. Pediatr Dermatol 1995;12242- 244
PubMed Link to Article
Carvalho  VOTaniguchi  KGiraldi  S  et al.  Congenital plaquelike glomus tumor in a child. Pediatr Dermatol 2001;18223- 226
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

A male infant at 1 month of age (case 1) with a red-purple plaque on the inner thigh and atrophy of the overlying cutis.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

The patient in Figure 1 (case 1) at 2½ years of age. Lesions on the inner thigh have become more pronounced and nodular and do not change with compression of the area.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

A girl at 9 years of age (case 5) with thickened purple nodules on the thigh.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

A male infant (case 10). A, As a neonate, he had pink patches with a surrounding dusky halo on his back. B, At 6 months of age, follow-up showed progression of the lesions with purple prominent vessels.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 5.

Case 3 at 2 years of age with a blue, thickened plaque on the face.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 2. Characteristics of 10 Cases of Congenital Plaque-Type GVM

References

Enjolras  OMulliken  JB Vascular tumors and vascular malformations (new issues). Adv Dermatol 1997;13375- 423
PubMed
Brouillard  PBoon  LMMulliken  JB  et al.  Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations (“glomangiomas”). Am J Hum Genet 2002;70866- 874
PubMed Link to Article
Boon  LMMulliken  JBEnjolras  OVikkula  M Glomuvenous malformation (glomangioma) and venous malformation: distinct clinicopathologic and genetic entities. Arch Dermatol 2004;140971- 976
PubMed Link to Article
Boon  LMBrouillard  PIrrthum  A  et al.  A gene for inherited cutaneous venous anomalies (“glomangiomas”) localizes to chromosome 1p21-22. Am J Hum Genet 1999;65125- 133
PubMed Link to Article
Boon  LMMulliken  JBVikkula  M  et al.  Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. Hum Mol Genet 1994;31583- 1587
PubMed Link to Article
Vikkula  MBoon  LMCarraway  KL  III  et al.  Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 1996;871181- 1190
PubMed Link to Article
Irrthum  ABrouillard  PEnjolras  O  et al.  Linkage disequilibrium narrows locus for venous malformation with glomus cells (VMGLOM) to a single 1.48 Mbp YAC. Eur J Hum Genet 2001;934- 38
PubMed Link to Article
Rudolph  R Familial multiple glomangiomas. Ann Plast Surg 1993;30183- 185
PubMed Link to Article
Tran  LPVelanovich  VKaufmann  CR Familial multiple glomus tumors: report of a pedigree and literature review. Ann Plast Surg 1994;3289- 91
PubMed Link to Article
Happle  RKonig  A Type 2 segmental manifestation of multiple glomus tumors: a review and reclassification of 5 case reports. Dermatology 1999;198270- 272
PubMed Link to Article
Brouillard  PGhassibe  MPenington  A  et al.  Four common glomulin mutations cause two thirds of glomuvenous malformations (“familial glomangiomas”): evidence for a founder effect. J Med Genet 2005;42e13
PubMed Link to Article
Taaffe  ABarker  DWyatt  EHBury  HP Glomus tumours: a clinico-pathological survey. Clin Exp Dermatol 1980;5219- 225
PubMed Link to Article
Farmer  ERedHood  AFed Pathology of the Skin.  East Norwalk, Conn Appleton & Lange1994;827- 834
Tarnowski  WMHashimoto  K Multiple glomus tumors: an ultrastructural study. J Invest Dermatol 1969;52474- 478
PubMed
Dervan  PATobbia  INCasey  MO’Loughlin  JO’Brien  M Glomus tumours: an immunohistochemical profile of 11 cases. Histopathology 1989;14483- 491
PubMed Link to Article
Kaye  VMDehner  LP Cutaneous glomus tumor: a comparative immunohistochemical study with pseudoangiomatous intradermal melanocytic nevi. Am J Dermatopathol 1991;132- 6
PubMed Link to Article
McIntyre  BABrouillard  PAerts  VGutierrez-Roelens  IVikkula  M Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse. Gene Expr Patterns 2004;4351- 358
PubMed Link to Article
Landthaler  MBraun-Falco  OEckert  FStolz  WDorn  MWolff  HH Congenital multiple plaquelike glomus tumors. Arch Dermatol 1990;1261203- 1207
PubMed Link to Article
Goodman  TFAbele  DC Multiple glomus tumors: a clinical and electron microscopic study. Arch Dermatol 1971;10311- 23
PubMed Link to Article
Glick  SAMarkstein  EAHerreid  P Congenital glomangioma: case report and review of the world literature. Pediatr Dermatol 1995;12242- 244
PubMed Link to Article
Carvalho  VOTaniguchi  KGiraldi  S  et al.  Congenital plaquelike glomus tumor in a child. Pediatr Dermatol 2001;18223- 226
PubMed Link to Article

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