A 53-year-old woman presented with a 3-month history of tenderness and focal ulceration of the left breast. The area involved measured 4 × 3 cm and demonstrated reticulated erythematous induration and focal ulceration (Figure 1). Deeper tender nodularity was also observed. The patient's medical history included coronary cardiovascular disease with coronary artery bypass grafting performed 10 years earlier, familial type II hyperlipidemia, angina, fibromyalgia, and osteoporosis. She also had a family history of coronary artery disease. At the time of presentation, she was taking multiple medications, including valsartan (Diovan, 80 mg/d), metoprolol succinate (Toprol XL, 50 mg/d), atorvastatin (Lipitor, 40 mg/d), ezetimibe (Zetia, 10 mg/d), clopidogrel (Plavix, 75 mg/d), aspirin (81 mg/d), folic acid (800 μg/d), bumetanide (1 mg/d), diazepam (1000 mg/d), and calcium with vitamins daily.