In 2001, a report on intralesional injection of phosphatidylcholine for the reduction of protuberant lower eyelid fat suggested that fat could be dissolved by this substance. Subsequently, physicians used phosphatidylcholine as a “fat burner” to reduce saddlebag trochanteric bulges (breeches) and pendulous abdomens.1 To prove the ability of phosphatidylcholine to reduce fat, a pilot study for the treatment of lipomas was designed (Table). It was conducted according to good clinical practice guidelines with ethics committee approval. Fifteen volunteers (5 women and 10 men) aged 21 to 64 years (median age, 43.5 years) with 19 lipomas in various body sites were recruited for the study. All sought treatment for functional or aesthetic reasons. At baseline, before the first treatment, and at the end of follow-up (week 12), photographic documentation was performed and ultrasound imaging was used to evaluate 3 dimensions of each lipoma: thickness, length, and diameter at a 90° angle to the length, and their volume was calculated as ellipsoids (v = a:2×b:2×c:2×π×4:3).
Ultrasound images of a lipoma before (A) and after (B) 3 intralesional applications of phosphatidylcholine. The higher echographic density in the follow-up ultrasound image represents fibrosis of the lipoma. Note that the a and b axes in part A are reversed in part B.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Dermatology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 14
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.