To our knowledge, there have been no reports describing the treatment of sarcoidosis with adalimumab. Adalimumab is a fully human, monoclonal antibody directed against TNF-α. Given that adalimumab targets the same cytokine as infliximab and etanercept, one would expect that adalimumab may also be effective in the treatment of sarcoidosis. Treatment with adalimumab has advantages over infliximab in drug delivery. Adalimumab is administered subcutaneously once weekly or every other week by the patient at home, which most patients find to be convenient. Patients can be instructed on proper injection technique at an office visit. Infliximab, by contrast, is delivered intravenously in the physician’s office. This requires routine office visits and vital sign monitoring by a health care professional. Infusion reactions, such as allergic reactions (pruritis, urticaria) and cardiopulmonary effects (hypotension, hypertension, tachycardia), occur in about 9% of patients.23 In addition, because adalimumab is fully human, patients may be less likely to form antibodies against the medication. Adalimumab is approved by the FDA for the treatment of moderate to severe rheumatoid arthritis and is, therefore, available on the market.