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Infliximab Combined With Methotrexate as Long-term Treatment for Erythrodermic Psoriasis

Hannele Heikkilä, MD, PhD; Annamari Ranki, MD, PhD; Suvi Cajanus, MD; Seija-Liisa Karvonen, MD, PhD
Arch Dermatol. 2005;141(12):1607-1610. doi:10.1001/archderm.141.12.1607.
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Severe erythrodermic psoriasis, unresponsive to systemic treatments, is disabling for the patient and a challenge for dermatologists. Methotrexate, cyclosporine, and acitretin have been the treatments of choice.1 However, long-term therapy with these drugs often leads to difficult complications or adverse effects. Thus, new biologic agents such as tumor necrosis factor (TNF) inhibitors provide a welcome alternative. In controlled clinical trials, infliximab has proven to be an effective and fast-acting treatment for plaque-type psoriasis.24

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Long-term results of infliximab treatment. Patient 2 before infliximab treatment (A) and after 14 months of treatment (B).

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