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Clinical Recognition of Actinic Keratoses in a High-Risk Population How Good Are We? FREE

Suraj S. Venna, MD; Dennis Lee, MD; Miguel J. Stadecker, MD, PhD; Gary S. Rogers, MD
[+] Author Affiliations

Author Affiliations: Department of Dermatology, Dermatologic Surgery, and Pathology, Tufts University School of Medicine, Boston, Mass (Drs Venna, Lee, Stadecker, and Rogers), and the Department of Dermatology, Boston University School of Medicine, Boston (Dr Venna).


Arch Dermatol. 2005;141(4):507-509. doi:10.1001/archderm.141.4.507.
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Published online

ABSTRACT

Background  Actinic keratoses (AKs) are dysplastic epidermal lesions considered to be potential precursors of squamous cell carcinoma. Most AKs are diagnosed clinically and are rarely confirmed histologically. High interobserver variation exists among dermatologists for the diagnosis of AKs. Previous studies of the positive predictive value of the diagnosis of AKs have yielded rates as high as 94%. This study evaluates the rate at which histologic analysis confirms the clinical impression (positive predictive value) of AKs in patients with a history of skin cancer.

Observations  Seventeen (74%) of 23 lesions with classic features of AKs, as determined by 3 dermatologists, were confirmed as AKs histologically. These were lesions that would ordinarily not be biopsied. Of the 6 misdiagnoses, 5 (83%) were skin cancer, most often squamous cell carcinoma.

Conclusions  The positive predictive value of 74% for the diagnosis of AKs in this study is substantially lower than that of 2 previous studies, suggesting that physicians may be misdiagnosing many patients with classic features of AKs. Most misdiagnosed cases were forms of skin cancer. These preliminary data suggest that the threshold for biopsy of suspect lesions in patients with a history of skin cancer should be low and warrant further evaluation.

Figures in this Article

Actinic keratoses (AKs) are dysplastic epidermal lesions that are precursors of invasive squamous cell carcinoma (SCC). Various studies13 during the past 15 years have determined a rate of conversion of AKs to SCC of 0.1% to 10%. In 2002, more than 1 million cases of nonmelanoma skin cancers (NMSCs) were diagnosed in the United States.4 Squamous cell carcinoma accounts for more than 20% of NMSC and most metastatic disease and death due to NMSC. Therefore, the ability of the physician to distinguish precancerous lesions with a high degree of accuracy is invaluable and will decrease the morbidity and mortality of SCC.

The diagnosis of AKs is frequently made by dermatologists. Feldman et al5 determined that in a 4-year period, there were 127 million office visits to dermatologists, of which 14.6 million (11.5%) were for the evaluation and treatment of AKs. Yet, most AKs are diagnosed clinically, with few histologic confirmations. The clinical features of AKs are nonspecific, usually described as red, scaly papules or plaques, 2 to 5 mm in diameter, occurring in sun-exposed sites. They may bleed or become hypertrophic, at which point a biopsy is generally performed to evaluate for progression to SCC. The diagnostic accuracy or positive predictive value (PPV) of the clinical diagnosis of AKs would require biopsy confirmation.

Although a variety of studies have examined the rate of misclassification of AKs as suspected skin cancers, no study has exclusively examined the accuracy of the clinical diagnosis of AKs as confirmed by histologic examination.6 The question we are asking is how often the skin biopsy findings confirm the clinical impression of AK in a population at risk for NMSC.

METHODS

Patients who were seen at the Department of Dermatologic Surgery at Tufts–New England Medical Center for definitive surgical treatment of skin cancer were consecutively examined by a team of dermatologists for the presence of AKs during a 6-week period. The examiners included 2 board-certified dermatologists and a second-year dermatology resident. Every patient presenting for surgery was examined, and the first 18 patients who satisfied the inclusion and exclusion criteria (Table) underwent a biopsy of the presumed AK. All members of the team had to agree that the lesion represented a classic AK, a lesion that would not ordinarily warrant a biopsy examination. A classic AK was defined as an erythematous papule 2 to 5 mm in diameter, with an adherent scale and a palpable rough surface (Figure). Lesions that were indeterminate or hypertrophic were not included.

Table Graphic Jump LocationTable. Inclusion and Exclusion Criteria
Place holder to copy figure label and caption
Figure.

Right nasojugal fold with a 4-mm erythematous, scaly papule with histologic confirmation.

Graphic Jump Location

For each patient, skin examinations of sun-exposed areas were performed, with special attention to the scalp, face, and dorsal hands. Patients were made aware of the purpose of this pilot study and agreed to have suspect lesions biopsied after informed consent was obtained.

A spreadsheet was devised that included the patient’s medical record number, date, site of biopsy, site of skin cancer, clinical impression, and pathologic diagnosis. All 23 lesions were histologically evaluated by a single dermatopathologist (M.J.S.). Two lesions, which were acquired from a Tufts–New England Medical Center satellite office, were submitted to another dermatopathologist. All the lesions that were initially read as AK were then reread in a masked manner, with 100% intraobserver concordance.

RESULTS

In this pilot study, 23 lesions with classic clinical features of AKs were identified in 18 patients (6 women and 12 men) presenting for surgical treatment of skin cancer. The mean age of the cohort was 67 years, and the most common presenting skin cancer was basal cell carcinoma (BCC) (n = 11), followed by SCC (n = 6) and melanoma in situ (n = 1). The 23 lesions presumed to be AKs were histologically evaluated. Seventeen of these lesions were confirmed histologically to be AKs, yielding a PPV of 74%. Of the 6 lesions that were not AKs, 3 were SCC, 1 was BCC, 1 was lentigo maligna, and 1 was a collision lesion of an irritated seborrheic keratosis with an AK.

COMMENT

The present pilot study of 18 high-risk patients (skin phototype I or II) with 23 lesions yielded a PPV of 74% for diagnosing AKs in which only lesions with clinically classic features of AKs were biopsied. In a population of patients with a high prevalence of skin cancer, we would expect to have more than 95% PPV for the diagnosis of AKs. Physicians are misdiagnosing a substantial proportion of patients with classic features of AKs. In addition, of the lesions that were not AKs histologically, 5 (83%) of 6 were forms of skin cancer (3 SCC, 1 BCC, and 1 lentigo maligna).

The differential diagnosis of a classic AK includes seborrheic keratoses, stucco keratoses, arsenical keratoses, developing keratoacanthoma, discoid lupus erythematosus, acantholytic acanthoma, psoriasis, acrokeratosis verruciformis, SCC, BCC, and Bowen disease.7,8 This broad differential underscores the highly nonspecific clinical features of AKs. The present pilot study shows that in a population of patients with a high prevalence of skin cancer, it would be prudent for physicians to have a lower threshold to biopsy suspected lesions rather than repeatedly treating them with liquid nitrogen or other methods.

Weinstock et al9 examined the reliability of dermatologists to count AKs and found a substantial degree of interobserver variation, even with experienced dermatologists. Whited et al10 examined the ability of primary care physicians to diagnose AKs and NMSC using dermatologists’ clinical impressions as the gold standard and found again that for the diagnosis of AKs, the interobserver variability among dermatologists was unreliable.

Marks et al11 examined the presence of AKs as a predictive factor for a person’s potential to develop NMSCs. Most AKs were diagnosed clinically, except in doubtful cases, when a biopsy was performed. The examiners, including a consultant dermatologist, a dermatology registrar, and a medical student, were tested for their ability to correctly diagnose AKs in a previous study.12 Their PPV was 94% (34/36). One lesion was found to be a seborrheic keratosis, and the other showed normal histologic findings except for solar elastosis.

The only other data examining PPV for the diagnosis of AKs were collected in a study13 investigating the reduction of AKs with the regular use of sunscreen. Of 588 patients with clinically diagnosed AKs, 48 were chosen at random for biopsy examination as a measure of diagnostic accuracy. Thirty-nine of the 48 lesions, or 81% PPV, were histologically confirmed AKs. None of the missed lesions were skin cancers. The histologic findings of the 9 lesions that were not AKs were as follows: 1 each spongiotic dermatitis, hemangioma, and benign papilloma; 2 stucco keratoses; and 4 with severe solar damage and inflammatory changes in the dermis.

Although various prevalence rates of AKs are quoted in the literature, the true rate cannot be determined unless histologic confirmation is made. Moy14 makes the statement that “there is no definite way to distinguish between an actinic keratosis and a squamous cell carcinoma without performing a biopsy . . . many lesions thought to be actinic keratoses are actually squamous cell carcinomas but are treated as actinic keratoses.”

Most epidemiologic studies are based solely on the clinical skin examination. At least 8 epidemiologic studies in Australia and 5 studies outside of Australia (3 in the United States, 1 in Ireland, and 1 in Wales) have examined the prevalence of AKs. All were limited owing to a lack of histologic validation of the clinical impression.6

The presence of AKs not only is a measure of sun damage but, more importantly, also identifies a high-risk group of patients predisposed to the development of invasive SCC and BCC6,15,16 and, to a lesser extent, melanoma.17,18 A larger multicenter study is needed to further validate these observations.

ARTICLE INFORMATION

Correspondence: Gary S. Rogers, MD, Department of Dermatology, Dermatologic Surgery, and Pathology, Tufts University School of Medicine, Biewend Bldg, 13th Floor, Boston, MA 02111.

Accepted for Publication: July 22, 2004.

Financial Disclosure: None.

REFERENCES

Marks  RFoley  PGoodman  G  et al.  Spontaneous remission of solar keratoses: the case for conservative management Br J Dermatol 1986;115649- 655
PubMed Link to Article
Marks  RRennie  GSelwood  TS Malignant transformation of solar keratoses to squamous cell carcinoma in the skin: a prospective study Lancet 1988;1795- 797
PubMed Link to Article
Dodson  JMDeSpain  JHewett  JEClark  DP Malignant potential of actinic keratoses and the controversy over treatment: a patient-oriented perspective Arch Dermatol 1991;1271029- 1031
PubMed Link to Article
Jemal  AThomas  AMurray  TThun  M Cancer statistics, 2002 CA Cancer J Clin 2002;5223- 47
PubMed Link to Article
Feldman  SRFleischer  ABMcConnell  C Most common dermatologic problems identified by internists, 1990-1994 Arch Intern Med 1998;158726- 730
PubMed Link to Article
Frost  CAGreen  AC Epidemiology of solar keratoses Br J Dermatol 1994;131455- 464
PubMed Link to Article
Wilkerson  MGGoldberg  LHRapini  RP Actinic keratoses Am Fam Physician 1984;30103- 108
PubMed
Schwartz  RAStoll  HLFitzpatrick  TBedEisen  AZedWolf  Ked  et al.  Epithelial precancerous lesions Dermatology in General Medicine New York, NY McGraw-Hill Co1999;823- 826
Weinstock  MABingham  SFCole  GW  et al.  Reliability of counting actinic keratoses before and after brief consensus discussion: the VA Topical Tretinoin Chemoprevention Trial (VATTC) Arch Dermatol 2001;1371055- 1058
PubMed
Whited  JDHall  RPSimel  DLHorner  RD Primary care clinicians’ performance for detecting actinic keratoses and skin cancer Arch Intern Med 1997;157985- 990
PubMed Link to Article
Marks  RRennie  GSelwood  T The relationship of basal cell carcinomas and squamous cell carcinomas to solar keratoses Arch Dermatol 1988;1241039- 1042
PubMed Link to Article
Ponsford  MWGoodman  GMarks  R The prevalence and accuracy of diagnosis of non-melanotic skin cancer in Victoria Australas J Dermatol 1983;2479- 82
PubMed Link to Article
Thompson  SCJolley  DMarks  R Reduction of solar keratoses by regular sunscreen use N Engl J Med 1993;3291147- 1151
PubMed Link to Article
Moy  R Clinical presentation of actinic keratoses and squamous cell carcinoma J Am Acad Dermatol 2000;428- 10
PubMed Link to Article
Green  ABattistutta  D Incidence and determinants of skin cancer in a high-risk Australian population Int J Cancer 1990;46356- 361
PubMed Link to Article
Bataille  VSasieni  PGrulich  A  et al.  Solar keratoses: a risk factor for melanoma but negative association with melanocytic naevi [abstract] Int J Cancer 1998;788- 12
PubMed Link to Article
Green  ACO’Rourke  MG Cutaneous melanoma in association with other skin cancers J Natl Cancer Inst 1985;74977- 980
PubMed
Dubin  NMoseson  MPasternak  BS Epidemiology of malignant melanoma: pigmentary traits, ultraviolet radiation and the identification of high-risk populations Recent Results Cancer Res 1986;10256- 75
PubMed

Figures

Place holder to copy figure label and caption
Figure.

Right nasojugal fold with a 4-mm erythematous, scaly papule with histologic confirmation.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Inclusion and Exclusion Criteria

References

Marks  RFoley  PGoodman  G  et al.  Spontaneous remission of solar keratoses: the case for conservative management Br J Dermatol 1986;115649- 655
PubMed Link to Article
Marks  RRennie  GSelwood  TS Malignant transformation of solar keratoses to squamous cell carcinoma in the skin: a prospective study Lancet 1988;1795- 797
PubMed Link to Article
Dodson  JMDeSpain  JHewett  JEClark  DP Malignant potential of actinic keratoses and the controversy over treatment: a patient-oriented perspective Arch Dermatol 1991;1271029- 1031
PubMed Link to Article
Jemal  AThomas  AMurray  TThun  M Cancer statistics, 2002 CA Cancer J Clin 2002;5223- 47
PubMed Link to Article
Feldman  SRFleischer  ABMcConnell  C Most common dermatologic problems identified by internists, 1990-1994 Arch Intern Med 1998;158726- 730
PubMed Link to Article
Frost  CAGreen  AC Epidemiology of solar keratoses Br J Dermatol 1994;131455- 464
PubMed Link to Article
Wilkerson  MGGoldberg  LHRapini  RP Actinic keratoses Am Fam Physician 1984;30103- 108
PubMed
Schwartz  RAStoll  HLFitzpatrick  TBedEisen  AZedWolf  Ked  et al.  Epithelial precancerous lesions Dermatology in General Medicine New York, NY McGraw-Hill Co1999;823- 826
Weinstock  MABingham  SFCole  GW  et al.  Reliability of counting actinic keratoses before and after brief consensus discussion: the VA Topical Tretinoin Chemoprevention Trial (VATTC) Arch Dermatol 2001;1371055- 1058
PubMed
Whited  JDHall  RPSimel  DLHorner  RD Primary care clinicians’ performance for detecting actinic keratoses and skin cancer Arch Intern Med 1997;157985- 990
PubMed Link to Article
Marks  RRennie  GSelwood  T The relationship of basal cell carcinomas and squamous cell carcinomas to solar keratoses Arch Dermatol 1988;1241039- 1042
PubMed Link to Article
Ponsford  MWGoodman  GMarks  R The prevalence and accuracy of diagnosis of non-melanotic skin cancer in Victoria Australas J Dermatol 1983;2479- 82
PubMed Link to Article
Thompson  SCJolley  DMarks  R Reduction of solar keratoses by regular sunscreen use N Engl J Med 1993;3291147- 1151
PubMed Link to Article
Moy  R Clinical presentation of actinic keratoses and squamous cell carcinoma J Am Acad Dermatol 2000;428- 10
PubMed Link to Article
Green  ABattistutta  D Incidence and determinants of skin cancer in a high-risk Australian population Int J Cancer 1990;46356- 361
PubMed Link to Article
Bataille  VSasieni  PGrulich  A  et al.  Solar keratoses: a risk factor for melanoma but negative association with melanocytic naevi [abstract] Int J Cancer 1998;788- 12
PubMed Link to Article
Green  ACO’Rourke  MG Cutaneous melanoma in association with other skin cancers J Natl Cancer Inst 1985;74977- 980
PubMed
Dubin  NMoseson  MPasternak  BS Epidemiology of malignant melanoma: pigmentary traits, ultraviolet radiation and the identification of high-risk populations Recent Results Cancer Res 1986;10256- 75
PubMed

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