0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Observation |

Cutaneous Gamma-Delta T-Cell Lymphoma Successfully Treated With Brentuximab Vedotin ONLINE FIRST

Belen Rubio-Gonzalez, MD1; Jasmine Zain, MD2; Lino Garcia, MS3; Steven T. Rosen, MD2; Christiane Querfeld, MD, PhD1,2,4
[+] Author Affiliations
1Department of Pathology, City of Hope, Duarte, California
2Department of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, California
3Division of Cytogenetics, City of Hope, Duarte, California
4Department of Surgery, Division of Dermatology, City of Hope, Duarte, California
JAMA Dermatol. Published online September 21, 2016. doi:10.1001/jamadermatol.2016.3117
Text Size: A A A
Published online

Extract

This case report describes a case of cutaneous gamma-delta T-cell lymphoma successfully treated with brentuximab vedotin.

Primary cutaneous gamma-delta T-cell lymphoma (GD-TCL) is a rare skin lymphoma with numerous clinical presentations. Cytotoxic features on histologic analysis and the T-cell receptor (TCR)-gamma expression on immunohistochemical analysis are clues that should raise suspicion for the diagnosis. Expression of CD30 can also be seen in some cases and should be evaluated because it allows for patients to be treated with brentuximab, as in the present case.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure 1.
Clinical Findings of Epidermotropic Cutaneous Gamma-Delta T-Cell Lymphoma and Clinical Response to Brentuximab

A, Multiple necrotic papules and small scaly plaques on the anterior trunk. B, Partial clearing of skin lesions after 4 cycles of brentuximab vedotin treatment.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Histopathologic and Fluorescence in Situ Hybridization (FISH) Images

A, Epidermal infiltration of atypical large pleomorphic lymphocytes with associated dyskeratotic and apoptotic keratinocytes and partial ulceration; the underlying superficial dermis shows a bandlike lymphohistiocytic infiltrate. B, Detail of the large cells with clumped chromatin. C, Most of the large cells show T-cell receptor (TCR)-gamma expression by immunohistochemical analysis. D, The results of FISH analysis using X and Y probes (green and red spots, respectively) revealed that the atypical lymphoid cells in epidermis (above the curved line) showed a male (XY) host pattern, while dermal cells (below the curved line) showed a predominant female (XX) donor pattern with scattered male (XY) positive cells.

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

50 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
Jobs
brightcove.createExperiences();