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JAMA Dermatology Clinical Evidence Synopsis |

Safety of Topical Corticosteroids in Pregnancy

Ching-Chi Chi, MD, MMS, DPhil, FAAD1; Shu-Hui Wang, MD, MS2; Gudula Kirtschig, MD, PhD3
[+] Author Affiliations
1Department of Dermatology and Centre for Evidence-Based Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Chiayi, Taiwan
2Department of Dermatology, Far Eastern Memorial Hospital, New Taipei, Taiwan
3Institute of General Medicine and Interprofessional Care, University of Tübingen, Tübingen, Germany
JAMA Dermatol. 2016;152(8):934-935. doi:10.1001/jamadermatol.2016.1009.
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ABSTRACT

Clinical Question  Are topical corticosteroids safe for use in pregnancy?

Bottom Line  The available evidence found no associations of maternal use of topical corticosteroids of any potency with mode of delivery, birth defects, preterm delivery, fetal death, and low Apgar score. However, maternal use of potent to very potent topical corticosteroids, especially when the cumulative dosage of topical corticosteroids throughout the pregnancy is very large, is associated with low birth weight.

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