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Research Letter |

Ovoid Palatal Patch in Dermatomyositis A Novel Finding Associated With Anti-TIF1γ (p155) Antibodies

Laura L. Bernet, MD1; Matthew A. Lewis, MD1; Kerri E. Rieger, MD, PhD1,2; Livia Casciola-Rosen, PhD3; David F. Fiorentino, MD, PhD1
[+] Author Affiliations
1Department of Dermatology, Stanford University School of Medicine, Redwood City, California
2Department of Pathology, Stanford University School of Medicine, Stanford, California
3Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
JAMA Dermatol. 2016;152(9):1049-1051. doi:10.1001/jamadermatol.2016.1429.
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This study evaluates the clinical and laboratory associations of the ovoid palatal patch, which is often found in patients with dermatomyositis.

Dermatomyositis (DM) is a heterogeneous disease with a multitude of physical findings and clinical presentations, and patients with anti–transcriptional intermediary factor-1γ (TIF1γ) antibodies have distinct cutaneous features and are also at increased risk for cancer.1 We describe a novel, distinctive patch on the hard palate, which is associated with anti-TIF1γ antibodies that may identify patients at higher risk of cancer.

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Clinical and Histopathologic Photographs of the Ovoid Palatal Patch

A and B, Clinical images from 2 patients, both showing the typical arcuate symmetric erythema on the hard palate intermixed with white macules. C-E, Biopsy specimens from an ovoid palatal patch showing an interface dermatitis with dyskeratotic keratinocytes (C, original magnification ×20), a markedly thickened basement membrane (D, original magnification ×40), and increased dermal mucin (E, original magnification ×40).

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