0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Dermatology |

Highlights FREE

JAMA Dermatol. 2016;152(4):361. doi:10.1001/jamadermatol.2015.3247.
Text Size: A A A
Published online

RESEARCH

Polycystic ovary syndrome (PCOS) affects 2% to 7% of women, and many of these women experience some of the classic cutaneous findings of acne, hirsutism, and androgenic alopecia. In this retrospective cross-sectional study, Schmidt et al demonstrate that, although acne is common in women with PCOS, it did not distinguish between women suspected of having PCOS and those meeting the diagnostic criteria. Hirsutism and acanthosis nigricans were the most useful cutaneous indicators to distinguish those most at risk among a suspected PCOS population.

Metabolic syndrome is an integral part of polycystic ovary syndrome, and acne is commonly seen in this setting. In male patients, the association between insulin resistance and acne has been poorly investigated. In this cross-sectional study, Nagpal et al demonstrate that postadolescent men with acne more commonly had insulin resistance that may be a stage of prediabetes, and they may develop hyperinsulinemia or type 2 diabetes. These patients should be monitored for a prolonged time to determine whether they develop other conditions associated with insulin resistance.

Many studies have suggested that total number of nevi and atypical nevi (AN) are strongly associated with risk of melanoma. In this survey of patients with melanoma, Geller et al demonstrate that most patients with melanoma had few nevi and no AN. In younger patients, thick melanomas were commonly found in those with fewer total nevi, but more AN, suggesting that practitioners and patients should not rely on total nevus count to determine risk of melanoma. Younger patients with higher numbers of AN should be educated regarding their increased risk of thick melanoma.

Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer of the skin. Surgical removal offers an excellent prognosis in most cases, but nodal metastases and death are seen in a small number of cases. The absence of a national tumor registry for cSCC complicates the analysis of prognostic factors related to outcomes. In this meta-analysis, Thompson et al demonstrate that tumor depth is associated with the highest relative risk of local recurrence and metastasis of cSCC. Tumor diameter exceeding 20 mm was associated with the highest relative risk of disease-specific death.

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by painful, recurrent, suppurative abscesses in areas rich with apocrine sweat glands. Patients with HS carry a greater systemic inflammatory load, and HS may be associated with cardiovascular (CV) risk factors such as smoking, obesity, metabolic syndrome, and diabetes mellitus. In this population-based cohort study, Egeberg et aldemonstrate that HS was associated with a significantly increased risk of adverse CV outcomes and all-cause mortality independent of measured confounders. These results call for greater awareness of this association and for studies of its clinical consequences.

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

1,078 Views
0 Citations
×

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs