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Cutaneous Neonatal Lupus Arising in an Infant Conceived From an Oocyte Donation Pregnancy

Albert Sean Chiou, MD1; Grace Sun, MD2; Jinah Kim, MD, PhD1; Kevin Chun-Kai Wang, MD, PhD1; Ann L. Marqueling, MD1
[+] Author Affiliations
1Department of Dermatology, Stanford University School of Medicine, Palo Alto, California
2Dermatology Medical Group of Oxnard and Camarillo, Camarillo, California
JAMA Dermatol. 2016;152(7):846-847. doi:10.1001/jamadermatol.2016.0001.
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This case report describes cutaneous neonatal lupus in an infant conceived by oocyte donation pregnancy.

As the pathogenesis behind neonatal lupus erythematosus (NLE) is thought to require both gestational factors, such as circulating maternal autoantibodies, and an underlying fetal genetic susceptibility,1 we report an informative case of cutaneous NLE involving an infant conceived through in vitro fertilization with a healthy oocyte donor and a gestational mother with Sjögren syndrome (SS), demonstrating that direct inheritance of genetic susceptibility from a mother afflicted with autoimmunity is not required for NLE.

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Figure 1.
Cutaneous Neonatal Lupus

Clinical photograph of patient demonstrating characteristic annular, scaling plaque.

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Figure 2.
Punch Biopsy Specimen From a Facial Lesion

A punch biopsy performed on a scaling plaque on the patient’s face at age 4 weeks reveals a vacuolar interface dermatitis overlying a dense dermal infiltrate composed of neutrophils, lymphocytes, and histiocytes, supporting the diagnosis of neonatal lupus (hematoxylin-eosin, original magnification ×200).

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