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JAMA Dermatology Clinicopathological Challenge |

Blaschkoid Skin Lesions in a Young Girl QUIZ

Jake E. Turrentine, MD1; Katherine A. Gordon, MD2; Nnenna G. Agim, MD2,3
[+] Author Affiliations
1Division of Dermatology, The Medical College of Georgia at Augusta University, Augusta
2The University of Texas at Southwestern Medical Center, Dallas
3Children’s Medical Center, Dallas, Texas
JAMA Dermatol. 2016;152(6):713-714. doi:10.1001/jamadermatol.2016.0061.
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A young girl presented for care of skin lesions on her trunk and extremities that had been present since birth and an intermittent inflammatory reaction localized to the lesions; there was no history of developmental delay, eye abnormalities, or seizures. What is your diagnosis?

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A, Irregular, dark brown, well-demarcated macules within prominent soft, yellow, papular protrusions in a Blaschkolinear arrangement on the upper arms; linear, atrophic pink plaques with focal erosions and crusting are seen on the right flank. B, Extracutaneous features show syndactyly of the toes and ventral pterygium and dystrophy of the toe nails. C, Hematoxylin-eosin staining of skin biopsy demonstrates close proximity of subcutaneous fat to the epidermis with attenuated collagen (original magnification × 20).

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