0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Repetitive Application of Sunscreen Containing Titanium Dioxide Nanoparticles on Human Skin

Sergio G. Coelho, PhD1; Anil K. Patri, PhD2; Anna M. Wokovich, BS, Chem3; Scott E. McNeil, PhD2; Paul C. Howard, PhD4; Sharon A. Miller, MSEE5
[+] Author Affiliations
1Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
2Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland
3Division of Pharmaceutical Analysis, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, St Louis, Missouri
4National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas
5Division of Radiological Health, Office of In Vitro Diagnostics and Radiological Health, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland
JAMA Dermatol. 2016;152(4):470-472. doi:10.1001/jamadermatol.2015.5944.
Text Size: A A A
Published online

Extract

This study examines the relative risk of skin penetration by nanoscale TiO2 nanoparticles in healthy fair-skinned individuals.

Titanium dioxide (TiO2) has for decades been approved for use in sunscreens as a physical sunblock. It is not known whether reducing the size of TiO2 particles in sunscreens creates new issues of safety and/or effectiveness. A study was therefore conducted to investigate the relative risk of skin penetration by TiO2 nanoparticles in healthy fair-skinned individuals.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure.
TiO2 Nanoparticle Application and Maximal Dermal Presentation

A, Image made with light microscopy of a thick section. B, Images made with transmission electron microscopy (TEM) of thin sections from a study participant treated with titanium dioxide (TiO2)–containing sunscreen and showing maximal dermal presentation of TiO2 nanoparticles. Each boxed area in the image correlates with a TEM micrograph of a grid hole. Each grid hole is approximately 220 x 220 μm. The dotted pink line in the montage of TEM micrographs shows the division between epidermis and dermis. Grid holes 12 and 14 seen on TEM contain the epidermal layer and part of the dermal layer, whereas grid holes 13 and 15 contain only the dermal layer. A hair follicle structure was observed with TEM in this sample in grid holes 10 and 11. Electron-dense regions of the appropriate size and morphology to be TiO2 particles are indicated with dotted blue circles in the TEM micrographs. All particles were confirmed to contain TiO2 using scanning electron microscopy and energy dispersive X-ray spectroscopy as previously described.2

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

1,564 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Biological applications of gold nanoparticles. J Nanosci Nanotechnol 2014;14(1):344-62.
Jobs
brightcove.createExperiences();