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Treatment of Eosinophilic Fasciitis With Sirolimus

Vikash S. Oza, MD1; Rabina Walsh, MD2; Jeffrey North, MD2; Timothy G. Berger, MD2; Jenny E. Murase, MD2,3
[+] Author Affiliations
1Department of Dermatology, New York University School of Medicine, New York
2Department of Dermatology, University of California, San Francisco
3Department of Dermatology, Palo Alto Foundation Medical Group, Mountain View, California
JAMA Dermatol. 2016;152(4):488-490. doi:10.1001/jamadermatol.2016.0048.
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This case report describes the treatment of eosinophilic fasciitis with sirolimus.

Eosinophilic fasciitis (EF) is a disorder in which the subcutaneous tissues become indurated and then sclerotic leading to myalgia, arthralgia, and occasionally contractures and disability. High-dose systemic steroids are first-line therapy; however, steroid-sparing agents are often used owing to disease progression or to avoid the adverse effects of long-term corticosteroid use. We describe a case of EF with rapid response to sirolimus.

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Figure.
Clinical Images Taken Before and After 2 Months of Sirolimus Therapy

A, Induration and skin tightness causes discomfort and inability to make a fist. B, Much improved finger mobility allows the patient to make a fist after 2 months of sirolimus therapy.

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