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Erythema Dyschromicum Perstans Response to Isotretinoin

Fang Wang, MMS1; Yu-Kun Zhao, MMS2; Zhuo Wang, PhD3; Juan-Hua Liu, MMS2; Di-Qing Luo, MMS2
[+] Author Affiliations
1Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
3Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
JAMA Dermatol. 2016;152(7):841-842. doi:10.1001/jamadermatol.2015.6185.
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This case report describes the response of erythema dyschromicum perstans to treatment with isotretinoin

Erythema dyschromicum perstans (EDP), also called ashy dermatosis, is a rare acquired and chronic dermatosis, characterized by asymptomatically and progressively hyperpigmented macules of various size on the trunk, face, and extremities.1 Its exact cause is unknown, and its treatment remains controversial.1 We describe a 48-year-old Chinese man with EDP who was successfully treated with low-dose isotretinoin over a period of 7 years.

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Figure.
Clinical Views of Skin Lesions Before and 4 Months After Beginning Isotretinoin Treatment

A, Discrete and confluent ashy-gray macules and patches over the neck, forehead, face, and cheek. B, After 4 months of isotretinoin treatment, the lesions over the neck, forehead, face, and cheek have substantially improved.

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