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Radiation Recall Dermatitis With Concomitant Dabrafenib and Pazopanib Therapy

Sigurdis Haraldsdottir, MD1; Erin Bertino, MD2; Karl Haglund, MD, PhD3; Benjamin Kaffenberger, MD4; Manisha H. Shah, MD2
[+] Author Affiliations
1Division of Medical Oncology, Department of Internal Medicine, Stanford University, Stanford, California
2Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus
3Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center, Columbus
4Division of Dermatology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus
JAMA Dermatol. 2016;152(5):587-589. doi:10.1001/jamadermatol.2015.5366.
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This case report describes the occurrence of radiation recall dermatitis associated with concomitant dabrafenib and pazopanib therapy.

Radiation recall was first described in 1959 and is a tissue reaction that occurs in a previously irradiated area after administration usually of an antineoplastic or other class of agent.1 The incidence of radiation recall with targeted oncologic therapies is not well established. We report a case of radiation recall dermatitis occurring 3 days after initiation of combination therapy with dabrafenib and pazopanib.

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A, Highlighted is the intramedullary rod in the patient’s right femur (posterior view) and the posteroanterior radiation field that encompassed the entire intramedullary rod (marked with yellow). B, On day 4 of therapy, a reaction occurred on the patient’s posterior right thigh corresponding to the previously irradiated area. A scar from the prior rod placement can also be seen.

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