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Melanoma Gene Expression Markers for Surveillance of Epidermolysis Bullosa Nevi Malignant Transformation

Ji Won Ahn, BA1; Katherine Johnson, DO2; Laurie L. Kohen, MD2; Marsha L. Chaffins, MD2; Tor Shwayder, MD2
[+] Author Affiliations
1Washington University in St Louis School of Medicine, St Louis, Missouri
2Department of Dermatology, Henry Ford Hospital, Detroit, Michigan
JAMA Dermatol. 2016;152(5):584-586. doi:10.1001/jamadermatol.2015.5702.
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This case report of a young girl with epidermolysis bullosa (EB) describes melanoma gene expression markers that aid in thorough histopathologic examination of suspicious EB nevi lesions.

The evaluation of malignant changes in epidermolysis bullosa (EB) nevi remains a challenge for clinicians; herein, we introduce the idea of employing melanoma gene expression markers to aid in thorough histopathologic examination of suspicious EB nevi lesions.

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Figure 1.
Epidermolysis Bullosa Nevus at 9 Years of Age

A, A large, dark brown patch consisting of coalescing macules and satellite lesions is seen. B, Compound melanocytic proliferation is observed, demonstrating appropriate maturation, as is random atypia with large nested cells characterized by prominent nucleoli and heavy pigmentation (original magnification × 200).

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Figure 2.
Epidermolysis Bullosa Nevus at 12 Years of Age

A, The patch shows areas of regression on the medial and left upper borders. B, Compound melanocytic proliferation is observed marked by random nuclear atypia and broad areas of regressive fibrosis (original magnification ×100).

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