This case report describes well-differentiated syringofibrocarcinoma in a patient with Clouston syndrome.
An elderly man presented with syringofibrocarcinoma of the foot, which prompted examination and workup that confirmed a diagnosis of Clouston syndrome (hidrotic ectodermal dysplasia).
Article InformationCorresponding Author: Ian D. Odell, MD, PhD, Department of Dermatology, Yale University School of Medicine, PO Box 208059, New Haven, CT 06520 (Ian.Odell@yale.edu).
Published Online: January 20, 2016. doi:10.1001/jamadermatol.2015.4496.
Conflict of Interest Disclosures: None reported.
Additional Contributions: We thank the patient for granting permission to publish this information. We also thank Keith A. Choate, MD, PhD, Department of Dermatology, Yale University School of Medicine, who graciously let us use his laboratory for GJB6 sequencing.