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Editorial |

Genetic Testing for Melanoma—Where Are We With Moderate-Penetrance Genes?

Brigitte Bressac-de Paillerets, PharmD, PhD1,2; Pierre Vabres, MD, PhD3,4; Luc Thomas, MD, PhD5,6,7
[+] Author Affiliations
1Département de Biopathologie, Gustave Roussy, Villejuif, France
2INSERM U1186, Université Paris-Sud, Université Paris-Saclay, Villejuif, France
3Service de Dermatologie, CHU Dijon-Bourgogne, Dijon, France
4EA4271 Génétique des Anomalies du Développement, FHU Translad, Université de Bourgogne Franche-Comté, Dijon, France
5Service de Dermatologie, Centre Hospitaliser Lyon Sud, Pierre Bénite, France
6Université Claude Bernard Lyon 1, Villeurbanne, France
7Centre de Recherche sur le Cancer de Lyon, INSERM U1052–CNRS UMR5286, Centre Léon Bérard, Lyon, France
JAMA Dermatol. 2016;152(4):375-376. doi:10.1001/jamadermatol.2015.4359.
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Potrony et al1 studied a new category of cancer susceptibility genes conferring a moderately increased risk of developing cancer: a mutational hotspot in the microphthalmia transcription factor (MITF) gene, p.E318K.2,3 The main melanoma risk factors are UV light exposure and genetically determined host factors, such as nevus phenotype (atypical and multiple), fair skin, and familial or personal history of melanoma.

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